Epidural Analgesia and Maternal Fever During Labor

Fever Clinical Trial

Official title: Association Between the Effect of Epidural Analgesia and the Development of Maternal Fever During Labor: a Multicenter, Prospective, Observational, Cohort Study

Status Recruiting

Clinical Trial Summary

Women who receive epidural analgesia during labor are more likely to develop fever than those who do not. Maternal fever during labor can produce various harmful effects on both mothers and infants. The investigators speculate that the effect of epidural analgesia is associated with the development of maternal fever, i.e., better analgesia is associated with higher risk of maternal fever.

Clinical Trial Description

Epidural related maternal fever (ERMF) refers to the phenomenon of increased body temperature of parturient after receiving epidural analgesia during labor. Women who receive epidural labor analgesia are more likely to have fever than those who do not. In a systematic review, 20-33% of parturients receiving neuraxial analgesia developed fever during labor, compared with only 5-7% of those without neuraxial analgesia. Maternal fever can interfere with women's laboring process, decrease the sensitivity of the uterus and cervix to oxytocin, and lead to dystocia and increased surgical delivery rate. The investigators note that the rate of ERMF is lower in patients receiving lower density neuraxial blockade. The study is designed to test the hypothesis that the effect of epidural analgesia is associated with the development of maternal fever, i.e., better analgesia is associated with higher risk of maternal fever. ;

Related Conditions & MeSH terms

• Epidural Analgesia
• Fever

• NCT number: NCT04940091
• Study type: Observational [Patient Registry]
• Source: Peking University First Hospital
• Contact: Shuo Wang, MD
• Phone: 86 13521869490
• Email: 13521869490@163.com
• Status: Recruiting
• Start date: July 30, 2021
• Completion date: October 2022