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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01716169
Other study ID # 24915
Secondary ID
Status Completed
Phase N/A
First received October 25, 2012
Last updated March 27, 2014
Start date October 2012
Est. completion date November 2013

Study information

Verified date March 2014
Source Stanford University
Contact n/a
Is FDA regulated No
Health authority United States: Food and Drug AdministrationUnited States: Institutional Review Board
Study type Interventional

Clinical Trial Summary

The purpose of this study is to test the effectiveness of Helicoll (a collagen wound dressing) in treating chronic and non-chronic wounds of recessive dystrophic epidermolysis bullosa (RDEB) patients. Helicoll will be compared to standard wound dressings.


Recruitment information / eligibility

Status Completed
Enrollment 10
Est. completion date November 2013
Est. primary completion date November 2013
Accepts healthy volunteers No
Gender Both
Age group 7 Years and older
Eligibility Inclusion criteria:

1. Written consent must be obtained from subjects over age 18, or from a parent or legally authorized representative if subject is under 18. Assent will be obtained from subjects age 7 - 17.

2. Subjects with a clinical diagnosis of RDEB by a dermatologist.

3. Have at least three target wounds that meet the following criteria:

- One chronic wound, of approximately 6 months or more duration. If the subject has an additional chronic wound of similar size and duration, this additional wound will be treated with standard dressings and followed in the study. A wound in an area that consistently heals and then breaks down again will be considered a chronic wound.

- Two non-chronic wounds, of approximately 3 months or less duration, of similar size, and able to be dressed separately. Both wounds should have approximately the same duration.

All wounds must be:

- Open, and not scabbed or crusted over

- Not actively infected

- Not requiring surgical intervention

4. A parent or legally authorized representative must be willing and able to ensure subject is present for all required study visits (for minor subjects).

5. The subject or caregiver (or a parent or legally authorized representative for subjects under 18) must be able to follow instructions.

6. Subject must be age 7 or older.

Exclusion criteria:

1. Inability to travel to Stanford for study visits.

2. Complicating illness as determined by study investigators to be exclusionary including any infection requiring systemic antibiotics.

3. Presence or history of squamous cell carcinoma at target wound site.

4. Known bovine (cow) or ovine (sheep) sensitivity.

5. Therapy with an investigational agent during the study.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


Intervention

Device:
Helicoll
Helicoll Collagen I Wound Dressing
Standard of Care Dressings
Standard of Care wound dressings (e.g. Vaseline gauze)

Locations

Country Name City State
United States Stanford School of Medicine Stanford California

Sponsors (1)

Lead Sponsor Collaborator
Stanford University

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Proportion of wounds achieving 100% re-epithelialization at Week 8 Week 8 No
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