Clinical Trials Logo

Clinical Trial Summary

Lateral epicondylitis is a pathologic condition of the musculotendinous system, characterized by the presence of pain at the lateral epicondyle of the humerus; it is a tendinopathy of the extensor muscles of the forearm, often caused by overuse or repetitive use of the arm, forced extension of the elbow, or direct trauma to the humeral epicondyle. This study evaluated the efficacy of Extracorporeal ShockWave Treatment (ESWT) combined with a supplemental nutraceutical treatment of Hyaluronic Acid, Collagen, Vitamin C, and Manganese, compared with single treatment in patients with lateral epicondylitis in term of improvement in pain, functional capacity, muscle strength, and reduction of inflammation on ultrasound images. A clinical trial was conducted at the U.O.C. of "Recovery and Functional Rehabilitation" of A.O.U.P. "P. Giaccone" of Palermo from Marc 2024 to July 2024. Patients were randomized into 3 groups: in group "A", n° 5 sessions of focal ESWT were given every six days; in group "B", patients took daily for 30 days, supplemental nutraceutical treatment of Hyaluronic Acid, Collagen, Vitamin C, and Manganese; and group "C", patients had combined treatment of ESWT (one session every six days for a total of five sessions) and nutraceutical supplementation (one administration per day for one month). All patients were evaluated at enrollment (T0), after one month, at the end of rehabilitation treatment (T1), and at a follow up 30 days after the end of treatment (T2). Researched will compare patients treated with ESWT or with nutraceutical treatment, and patients who had combined treatment to see if there are real differences in term of pain reduction and improved short- and long-term quality of life.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06442618
Study type Interventional
Source University of Palermo
Contact Giulia Letizia Mauro
Phone +39 0916554160
Email giulia.letiziamauro@unipa.it
Status Recruiting
Phase N/A
Start date March 1, 2024
Completion date December 31, 2024

See also
  Status Clinical Trial Phase
Withdrawn NCT02861183 - Study of Sodium Hyaluronate to Provide Symptomatic Relief of Lateral Epicondylosis (Tennis Elbow) N/A
Recruiting NCT02304952 - Eccentric Exercise or Radiofrequent Microtenotomy as Treatment of Lateral Epicondylalgia N/A
Completed NCT02596659 - Effectiveness of Radial Extracorporeal Shockwave Therapy on Tennis Elbow N/A
Completed NCT00674622 - Prolotherapy for the Treatment of Chronic Lateral Epicondylitis Phase 2/Phase 3
Completed NCT06206109 - The Effect of Tendon Tears on Lateral Epicondylitis
Recruiting NCT04442321 - Ultrasound-Guided Percutaneous Electrical Stimulation on Radial Nerve in Patients With Lateral Epicondylalgia N/A
Not yet recruiting NCT04382144 - Levobupivacaine Versus Liposomal Bupivacaine (Exparel®) for Treatment of Pain and Disability in Lateral Epicondylitis Phase 4
Recruiting NCT03863847 - A Neurofeedback Treatment for Chronic Musculoskeletal Pain N/A
Completed NCT04576195 - Immediate Neurophysiological Effects of PENS on Radial Nerve in Patients With Lateral Epicondylalgia N/A
Recruiting NCT02343809 - Diacutaneous Fibrolysis on Lateral Epicondylitis Phase 3
Completed NCT05084664 - Effect of Premodulated Current Versus Diadynamic Current On the Management of Tennis Elbow. N/A
Completed NCT05039827 - Mobilition With Movement and Soft Tissue Mobiiztion in Tennis Elbow N/A
Recruiting NCT00395616 - Comparison Between Type A Botulinum Toxin Injection and Corticosteroid Injection in the Treatment of Tennis Elbow N/A
Completed NCT00130949 - ALGRX 4975 in the Treatment of Tennis Elbow Phase 2
Recruiting NCT06116175 - Lateral Epicondylitis Continuous Radiofrequency Microtenotomy N/A
Recruiting NCT05326763 - Functional and Electromyographical Changes After PRP or Dextrose Injection in Chronic Lateral Epicondylitis Phase 3
Completed NCT04454060 - Study on the Development of Arthroscopic Treatment of Refractory Tennis Elbow
Enrolling by invitation NCT04445727 - Efficacy of Vitamin C Supplement vs Spinal Manipulation to Treatment in Lateral Epicondylitis N/A
Completed NCT04454047 - Extracapsular Arthroscopic Treatment for Refractory Tennis Elbow——Mid-and-short Term Retrospective Study of 50 Cases
Recruiting NCT06382805 - Comparison of the Effects of Kinesio Tape and High-intensity Laser Therapy in Lateral Epicondylitis N/A