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Study of Dupilumab in Adult Participants With Active Eosinophilic Esophagitis (EoE)

Eosinophilic Esophagitis Clinical Trial

Official title:
A Randomized, Double-Blind, Parallel, Placebo-Controlled Study of the Efficacy, Safety and Tolerability of Dupilumab in Adult Patients With Active Eosinophilic Esophagitis

Clinical Trial Summary

The primary objective of the study is to assess the clinical efficacy of repeat subcutaneous (SC) doses of dupilumab, compared with placebo, to relieve symptoms in adult participants with active, moderate to severe Eosinophilic Esophagitis (EoE).

The secondary objectives of the study are:

- To assess the safety, tolerability, and immunogenicity of SC doses of dupilumab in adult participants with active, moderate to severe EoE

- To assess the effect of dupilumab on esophageal eosinophilic infiltration

- To evaluate the pharmacokinetics (PK) of dupilumab in adult participants with EoE

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02379052
Study type Interventional
Source Regeneron Pharmaceuticals
Contact
Status Completed
Phase Phase 2
Start date May 12, 2015
Completion date July 10, 2017
View Details
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