Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis

Status Completed

Clinical Trial Summary

This is a randomized, double-blind, placebo-controlled study of oral cromolyn sodium when made into a viscous preparation for the treatment of eosinophilic esophagitis.

Clinical Trial Description

Eosinophilic esophagitis is an antigen-mediated allergic disease of the esophagus characterized by symptoms of gastrointestinal complaints and eosinophilic inflammation limited to the esophagus. Currently, first line therapeutic recommendations include swallowed, topical steroids or dietary therapy. While both work for the majority of patients, they both have limitations. The investigators are examining the use of oral cromolyn sodium as a treatment for this condition. This medication is a non-steroid that is already approved for other conditions. When taken orally, it is essentially not absorbed systemically, so side effects are minimal. There is only 1 brief, retrospective report of its use in this condition suggesting it does not work. However, from studying swallowed, topical steroids, it may require formulating the medication into a viscous preparation for it to work. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02371941
Study type	Interventional
Source	University of Tennessee
Contact
Status	Completed
Phase	Phase 4
Start date	December 2014
Completion date	December 2017

View Details

See also
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