Nasal Nitric Oxide Levels in Eosinophilic Esophagitis (EoE)

Status Completed

Clinical Trial Summary

This study is aimed at understanding whether oral nitric oxide levels can be used as a non-invasive marker for the diagnosis and management of patient with eosinophilic esophagitis (EoE).

Clinical Trial Description

Nitric oxide (NO) is produced by activated eosinophils and oral NO levels are known to be elevated in asthma and eosinophilic bronchitis. The measurement of oral NO is a non-invasive,easy to perform low cost procedure that is used frequently in the diagnosis and management of asthma. The diagnosis of eosinophilic esophagitis (EoE) requires conscious sedation, an upper endoscopy with biopsy, and histologic evaluation of the biopsy specimen. This is a costly and somewhat invasive procedure. If oral NO was elevated as a result of activity of esophageal eosinophils in EoE, the measurement of oral NO may potentially be a very convenient and useful test in the evaluation and treatment of EoE. We propose a pilot study to determine if oral NO levels are elevated in patients with eosinophilic esophagitis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01929824
Study type	Observational
Source	Mayo Clinic
Contact
Status	Completed
Phase
Start date	August 2013
Completion date	September 25, 2019

View Details

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