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Dexpramipexole Dose-Ranging Biomarker Study in Subjects With Eosinophilic Asthma — EXHALE-1  

Asthma Clinical Trial

Official title:
A Randomized, Double-Blind, Placebo-Controlled Dose-Ranging Biomarker Study of the Effects of Dexpramipexole on Eosinophils in Subjects With Eosinophilic Asthma

Clinical Trial Summary

This is a randomized, double-blind, placebo-controlled, parallel-group, dose-ranging, multi-center study to evaluate the clinical effects of oral administration of dexpramipexole for 12 weeks on peripheral blood eosinophil count in subjects with eosinophilic asthma.

Clinical Trial Description

One hundred subjects will receive study drug or matching placebo over 12 weeks of consecutive dosing. Following a short Run-in Period, eligible subjects will enter the Primary Assessment Period and receive twice-daily dosing of study drug or placebo for 12 weeks. Following 12 weeks of treatment, subjects will enter a 12-week Eosinophil Recovery Period. The primary endpoint for the study is the change in blood absolute eosinophil count from Baseline to Week 12. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04046939
Study type Interventional
Source Knopp Biosciences
Contact
Status Completed
Phase Phase 2
Start date August 15, 2019
Completion date March 2, 2021
View Details
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