Environmental Exposure Clinical Trial
Official title:
Soap and the Removal of Diethylhexyl Phthalate From Hands: N-of-1 and Cross-Over Designs
The aim of the study is to evaluate the effectiveness in removing chemical exposure on hand, the investigators compare removal efficiency of Di-(2-ethylhexyl)phthalate (DEHP) on hands by hand washing with soap and water vs. water only. In two three-day N-of-1 trials, residual DEHP was measured in a single female adult who washed exposed hands with soap-and-water or water-only. Subsequently, a crossover study was performed by randomly assigning another 28 subjects equally to wash with soap-and-water or with water-only, and then each one received the other treatment 24 hrs later.
Three studies, consisting of two N-of-1 trials and one crossover study, were used to compare
the effect of handwashing with soap and water (intervention) and handwashing with water only
(placebo) on phthalate removal from hands. The soap was plain soap, consisting of vegetable
oil and sodium hydroxide. First, the investigators recruited one healthy female aged 25 yrs
to participate in two N-of-1 trials. In each trial, her hands would be exposed to DEHP and
then be treated with either soap intervention or placebo for three times over the course of
three days. The first trial started on 15 May 2013. On day one, after the subject prewashed
her hands, she allowed her hands to be exposed to a designated amount of DEHP. She then
washed them with water only and rinsed them sequentially in three separate polyethylene (PE)
bags, each containing 200 mL water to collect DEHP residue. One hour later, the same protocol
was followed, except the exposed hands were treated with soap and water instead of water only
(Figure 1a). The water rinsing in three separate bags remained the same. The pairs of studies
were repeated on two subsequent days (16 and 17 May).
In the second N-of-1 trial, which was also performed over three days (22-24 May), the
protocol using the same subject remained the same for all three days, except that the subject
underwent intervention first then placebo. The water rinsing remained the same.
A randomized 2 × 2 crossover study was subsequently conducted between June and September
2013. The investigators assigned one group of 7 females and 7 males to perform handwashing
with soap and water (intervention) and another group of 7 females and 7 males to perform
handwashing with water only (placebo). Briefly, on the first day, the two groups washed their
DEHP exposed hands using either soap and water or water only and then rinsed them in a PE bag
with 200 mL water to collect DEHP. After 24 hrs, the experiment was crossed-over with the
same two groups receiving the opposite treatments.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT05541653 -
The IGNITE Study on Concentrated Investment in Black Neighborhoods
|
N/A | |
Completed |
NCT04028791 -
Sickle Cell Trait and Exercise, Effect of Hot Environment
|
N/A | |
Not yet recruiting |
NCT05105386 -
The Impact of Synergies of Indoor Air Pollutants on Childhood Health and Wellbeing
|
||
Completed |
NCT05507944 -
FeNO Hairdressers Pilot
|
||
Completed |
NCT04146025 -
Nurtured in Nature
|
N/A | |
Recruiting |
NCT05179993 -
Detection of Microplastics in Human Granulosa Cells and in the Follicular Fluid of Women Undergoing ICSI Treatment
|
||
Completed |
NCT03444922 -
Effects of BPA on Insulin and Glucose Responses
|
N/A | |
Recruiting |
NCT03319927 -
Reducing Pesticide Exposures in Child Care Centers
|
N/A | |
Recruiting |
NCT05500690 -
Understanding Effects of Folic Acid on the Methylosome and Transcriptome of Women With Spina Bifida Affected Pregnancies
|
N/A | |
Recruiting |
NCT05394363 -
Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents
|
||
Completed |
NCT00021658 -
Effects of Pesticide Exposure on Neurodevelopment/Growth/Respiratory Health
|
N/A | |
Not yet recruiting |
NCT05315388 -
Effects of "Vitamin N" Nature Immersion Therapy on Stress Levels in Health Care Workers in the City of Bogotá
|
N/A | |
Recruiting |
NCT06107933 -
Developmental Impacts of Microplastics Exposure in Early Life
|
||
Completed |
NCT03631667 -
Ultralow Dose PAH Binary Mixture Study
|
Early Phase 1 | |
Completed |
NCT02540408 -
Detection and Characterization of COPD in Dairy Farmers
|
N/A | |
Completed |
NCT03440307 -
Intervention to Reduce Bisphenol A Exposure in Women
|
N/A | |
Completed |
NCT05160948 -
Change in Knowledge After Receiving Personal Air Pollution Results
|
||
Recruiting |
NCT05865782 -
Reconstructing Schoolyards With Greenery to Increase Schoolchildren's Physical Activity and Mitigate Climate Changes
|
N/A | |
Active, not recruiting |
NCT03215368 -
The Ma'Anshan Birth Cohort (MABC)
|
||
Recruiting |
NCT06083415 -
Early Breast Growth in Girls Aged 6 to 8 Years in the Current Environmental Context
|
N/A |