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Enthesopathy clinical trials

View clinical trials related to Enthesopathy.

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NCT ID: NCT06383195 Recruiting - Clinical trials for Enthesitis Related Arthritis

The Reliability and Validity of the Ankylosing Spondylitis Performance Index (ASPI) in Enthesitis-Related Arthritis

Start date: March 21, 2024
Phase:
Study type: Observational

This study assesses the test-retest reliability, construct validity, and minimal detectable change of the Ankylosing Spondylitis Performance Index (ASPI) in assessing the physical function of patients with Enthesitis-related arthritis (ERA).

NCT ID: NCT05942976 Completed - Clinical trials for Rheumatoid Arthritis

Enthesis Differences in Rheumatoid Arthritis and Axial Spondyloarthropathy

Start date: June 16, 2023
Phase:
Study type: Observational [Patient Registry]

The aim of this study is to investigate the sonographic differences in entheses in patients with Rheumatoid arthritis and Axial Spondyloarthropathy.

NCT ID: NCT04953871 Completed - Spondyloarthritis Clinical Trials

Enthesitis Assessment Before and After Anti-Tumor Necrosis Factor Treatment in Spondyloarthritis

Start date: January 2017
Phase: Phase 4
Study type: Interventional

Biological therapies should be considered in patients with high disease activity despite nonsteroid antiinflammatory drug treatment. The first option among biological therapies is anti-Tumor Necrosis Factor (anti-TNF) drugs. In recent years, anti-TNF treatments have shown that clinical and ultrasonographic enthesitis may improve as well as disease activity, quality of life and acute phase reactants. In this prospective study, we aimed to evaluate the clinical and ultrasonographic evaluation of enthesitis and to determine its response to anti-TNF treatment in patients with SpA.In this prospective study, we aimed to evaluate the clinical and ultrasonographic evaluation of enthesitis and to determine its response to anti-TNF treatment in patients with SpA.

NCT ID: NCT04887597 Active, not recruiting - Psoriatic Arthritis Clinical Trials

EBIO - Enthesitis Biopsy Study

EBIO
Start date: March 18, 2019
Phase: Phase 4
Study type: Interventional

The purpose of this Phase IV study is to determine the effect of secukinumab on total immune cell numbers obtaines by entheseal biopsy in the inflamed human entheses in patients with Psoriatic Arthritis. This is a single arm, single centre, prospective, open label study with secukinumab.

NCT ID: NCT04527380 Active, not recruiting - Clinical trials for Juvenile Psoriatic Arthritis

A Study of Ixekizumab (LY2439821) in Children With Juvenile Idiopathic Arthritis Categories of Enthesitis-related Arthritis (Including Juvenile Onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis

Start date: April 13, 2021
Phase: Phase 3
Study type: Interventional

The reason for this study is to see if the study drug ixekizumab is safe and effective in children with juvenile idiopathic arthritis (JIA) categories of enthesitis-related arthritis (ERA) (including juvenile onset ankylosing spondylitis [JoAS]) and juvenile psoriatic arthritis (JPsA).

NCT ID: NCT04232358 Active, not recruiting - Clinical trials for Achilles Entesopathy

Resistance Training and Injection Treatment for Achilles Enthesopathy

Start date: May 4, 2021
Phase: N/A
Study type: Interventional

Achilles enthesopathy is a common and often long-lasting injury among exercising individuals. Very little is known regarding the effect of different treatment strategies. The purpose of the study is to evaluate two treatment strategies for achilles enthesopathy: Resistance training and restricted loading + corticosteroid injection compared to resistance training and restricted loading + local anesthesia injection. 50 patients with achilles enthesopathy are randomly assigned to the two treatment groups in this double blinded RCT.

NCT ID: NCT04224597 Not yet recruiting - Acne Vulgaris Clinical Trials

Evaluation of the Presence of Enthesitis in Patients With Acne Vulgaris

Start date: February 1, 2020
Phase:
Study type: Observational

Acne vulgaris is an inflammatory disease of the pilosebaceous unit, affecting about 85% of the young population. In the studies p. acne is a potent stimulator of the release of IFN-gamma (IFN-)) and IL-17 from CD4 + T cells, and the presence of IL-17 + cells in the perifollicular infiltrate has been shown in biopsies of inflammatory acne lesions. Therefore, acne is thought to be a Th17-related disease (1). This study was aimed to evaluate the presence of enthesitis in patients with acne vulgaris.

NCT ID: NCT04209894 Completed - Enthesitis Clinical Trials

Detection of Subclinical Enthesitis by Ultrasonography

Start date: September 15, 2021
Phase:
Study type: Observational

Detection of subclinical enthesitis by ultrasonography

NCT ID: NCT03955861 Completed - Psoriasis Clinical Trials

Ultrasound Enthesitis Response in Psoriatic Arthritis

Start date: February 14, 2019
Phase:
Study type: Observational

The aim of this observational study will be to recruit 100 Psoriatic Arthritis (PsA) patients beginning on their biologic therapy and asses, both clinically and with the use of ultrasound (US), how enthesitis responds to biologic treatment. The decision to start treatment with a biologic therapy will be made by the patients' usual clinical rheumatology team, as part of their standard clinical care. This is independent of the study. Patients in whom treatment with these drugs for their PsA has been recommended will then be invited to participate in this study.They will then be commenced on biologic therapy at doses in line with the Summary of Product characteristics (SPC) for the product and followed up in the hospital outpatient clinic. Patients will have a full history taken and clinical exam performed prior to commencing on their prescribed biologic. The patient's history, Health Assessment Questionnaire scores and biobanking samples will be taken by the co-investigator. They will also calculate the patients tender and swollen joint score, dactylitis score, skin score, nail score and clinical enthesitis score.They will then have their tender entheseal points scanned as well as those as per the MASEI (Madrid Sonographic Enthesitis Index ) protocol by a single rheumatologist. The rheumatologist will be trained in ultrasound and will perform the scans blinded to this information both at initial consultation and at subsequent reviews. The patient will then commence their biologic treatment as planned at a separate review as per usual practise with their clinical team. Follow-up and final assessment at 4 months (±2 weeks) after starting biologic will include the clinical and ultrasound assessments as per the initial review and outlined in the schedule of assessments. They will also have a final blood sample taken at this point.

NCT ID: NCT03858504 Completed - Clinical trials for Enthesitis Related Arthritis

Yoga Versus Home Exercise Program in Children With Enthesitis Related Arthritis

Start date: July 31, 2019
Phase: N/A
Study type: Interventional

The aim of this study is to compare the effectiveness of different exercises programs as 'Yoga' and 'Home Exercise' in Enthesitis Related Arthritis.