Remote Ischemic Conditioning in Necrotizing Enterocolitis

Status Completed

Clinical Trial Summary

Necrotizing enterocolitis (NEC) affects up to 10% of very preterm infants. NEC mortality is high (30-50 %) and has remained unchanged over the last decades. New treatments are urgently needed. NEC pathogenesis is multifactorial, but bowel ischemia plays an essential role in NEC development. Remote ischemic conditioning (RIC) consists in inducing brief periods of non-lethal ischemia in a limb distant to an organ suffering from ischemia. RIC has been used in adults, children and term neonates with a variety of diagnosis. However, no study has been done including preterm infants with NEC.

Clinical Trial Description

An appropriately sized blood pressure cuff will be applied to an arm or leg and inflated to promote RIC. This study will be conducted in three phases to assess the feasibility and safety of RIC in relation to duration of ischemia time, number of cycles of RIC and whether it is feasible and safe to perform RIC on consecutive days. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03860701
Study type	Observational
Source	The Hospital for Sick Children
Contact
Status	Completed
Phase
Start date	December 17, 2018
Completion date	August 20, 2019

View Details

See also
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