Clinical Trials Logo
  1. Home
  2. Endotracheal Tube
  3. NCT06379139

Dynamic Full-field Optical Coherence Tomography for Structural and Microbiological Characterization of Endotracheal Tube Biofilm in Critically Ill Patients — BIOPAVIR2  

Critically Ill Clinical Trial

Official title:
Dynamic Full-field Optical Coherence Tomography for Endotracheal Tube Biofilm Characterization in Critically Ill Patients

Clinical Trial Summary

Biofilm is a microstructure organised into aggregates of microbiological species within a polymeric matrix. As early as the 2000s, the Centers for Disease Control and Prevention (CDC) recognised the possible role of the biofilm lining endotracheal endotracheal tubes in the development of ventilator-associated pneumonia (VAP) , the most common infection in intensive care, with a high morbidity and mortality rate and a significant increase in hospital costs. Targeting biofilm therefore now appears to be a new area of interest for limiting the risk of VAP, and this rationale has led to the development of an intraluminal for abrading biofilm deposited on the inside of the intubation probe . Evaluation of this type of strategy nevertheless justifies the introduction of more precise methods for characterisation of the biofilm. To this end, the investigator carried out an initial clinical study describing the biofilm on intubation probes, BIOPAVIR 1, showing the existence of several biofilm structures, each associated with a specific microbiological signature. Several limitations including a lack of power due to an insufficient number of patients and the use of number of patients, and the use of a confocal microscopy technique with poor axial without the possibility of acquiring metabolic images of the biofilm. Based on the previous description of biofilm by optical coherence tomography (OCT), and a recent experience with an optimised form of high-resolution OCT, called full-field OCT, the investigator hypothesise that full-field OCT will allow more accurate characterisation of biofilm, due to its high spatial resolution and its potential ability to capture metabolic activity in the biofilm BIOPAVIR 2 proposes to use the performance of full-field OCT to better characterise the biofilm lining endotracheal tubes in patients undergoing mechanical ventilation in intensive care units. This project represents a first step towards understanding the link between the development of biofilm on intubation and the occurrence of VAP

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06379139
Study type Observational
Source Centre Hospitalier Universitaire Dijon
Contact Thomas MALDINEY
Phone 385910474
Email thomas.maldiney@ch-chalon71.fr
Status Recruiting
Phase
Start date March 1, 2024
Completion date March 2025
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05539521 - Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation Phase 2
Recruiting NCT04776486 - Iohexol Clearance in Critically Ill Patients With Augmented Renal Creatinine Clearance N/A
Recruiting NCT05766319 - The ICU-recover Box, Using Smart Technology for Monitoring Health Status After ICU Admission N/A
Recruiting NCT03231540 - The PREServation of MUScle Function in Critically Ill Patients (PRESMUS) N/A
Completed NCT02286869 - Cardioventilatory Coupling in Critically Ill Patients N/A
Completed NCT01434823 - 24 Hour Intensivist Coverage in the Medical Intensive Care Unit N/A
Active, not recruiting NCT01142570 - Effect of Enteral Nutrition Enriched in Protein and Based on Indirect Calorimetry Measurement in Chronically Critically Ill Patients N/A
Completed NCT01167595 - Enhanced Protein-Energy Provision Via the Enteral Route in Critically Ill Patients N/A
Not yet recruiting NCT00916591 - Prokinetic Drugs and Enteral Nutrition N/A
Completed NCT01293708 - Realities, Expectations and Attitudes to Life Support Technologies in Intensive Care for Octogenarians:
Recruiting NCT00654797 - Improving Blood Glucose Control With a Computerized Decision Support Tool: Phase 2 Phase 2
Withdrawn NCT00178321 - Improving Sleep in the Pediatric Intensive Care Unit N/A
Completed NCT01168128 - PERFormance Enhancement of the Canadian Nutrition Guidelines by a Tailored Implementation Strategy: The PERFECTIS Study N/A
Completed NCT02447692 - Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study N/A
Recruiting NCT04582760 - Early Mobilization in Ventilated sEpsis & Acute Respiratory Failure Study N/A
Not yet recruiting NCT05961631 - Bio-electrical Impedance Analysis Derived Parameters for Evaluating Fluid Accumulation
Completed NCT03276650 - Admission of Adult-onset Still Disease Patients in the ICU
Completed NCT03922113 - Muscle Function After Intensive Care
Recruiting NCT05055830 - Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
Recruiting NCT06027008 - Mechanical Insufflation-Exsufflation (Cough Assist) in Critically Ill Adults N/A