Endothelial Function Clinical Trial
Official title:
The Effect of Blood Flow Restriction Resistance Training on Vascular Function: Wide-Rigid Cuffs vs. Narrow-Elastic Bands
Verified date | May 2024 |
Source | University of Texas at Austin |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to investigate the effect of blood flow restriction (BFR) resistance training on vascular function. The investigators aim to compare the effects of different BFR devices (wide-rigid cuffs and narrow elastic bands) on vascular function. The investigators hypothesize that BFR resistance training with wide-rigid cuffs might have a minor negative effect (short-term and reversible) on vascular function, while BFR resistance training with narrow-elastic bands may improve vascular function. Both training methods are equally effective in increasing muscle strength.
Status | Active, not recruiting |
Enrollment | 25 |
Est. completion date | July 2024 |
Est. primary completion date | June 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility | Inclusion Criteria: - Apparently healthy, sedentary or recreationally active young adults aged between 18 - 40 years old and signed the informed consent. Exclusion Criteria: - A current COVID-19 diagnosis - morbid obesity - hypertension - smoking - overt cardiovascular disease - using any medication that might affect the cardiovascular system - current participation in resistance training. |
Country | Name | City | State |
---|---|---|---|
United States | Cardiovascular Aging Research Laboratory | Austin | Texas |
Lead Sponsor | Collaborator |
---|---|
University of Texas at Austin |
United States,
Alhejily W, Aleksi A, Martin BJ, Anderson TJ. The effect of ischemia-reperfusion injury on measures of vascular function. Clin Hemorheol Microcirc. 2014;56(3):265-71. doi: 10.3233/CH-131741. — View Citation
Early KS, Rockhill M, Bryan A, Tyo B, Buuck D, McGinty J. EFFECT OF BLOOD FLOW RESTRICTION TRAINING ON MUSCULAR PERFORMANCE, PAIN AND VASCULAR FUNCTION. Int J Sports Phys Ther. 2020 Dec;15(6):892-900. doi: 10.26603/ijspt20200892. — View Citation
Horiuchi M, Okita K. Blood flow restricted exercise and vascular function. Int J Vasc Med. 2012;2012:543218. doi: 10.1155/2012/543218. Epub 2012 Oct 22. — View Citation
Hunt JE, Galea D, Tufft G, Bunce D, Ferguson RA. Time course of regional vascular adaptations to low load resistance training with blood flow restriction. J Appl Physiol (1985). 2013 Aug 1;115(3):403-11. doi: 10.1152/japplphysiol.00040.2013. Epub 2013 May 23. — View Citation
Lixandrao ME, Ugrinowitsch C, Berton R, Vechin FC, Conceicao MS, Damas F, Libardi CA, Roschel H. Magnitude of Muscle Strength and Mass Adaptations Between High-Load Resistance Training Versus Low-Load Resistance Training Associated with Blood-Flow Restriction: A Systematic Review and Meta-Analysis. Sports Med. 2018 Feb;48(2):361-378. doi: 10.1007/s40279-017-0795-y. — View Citation
Pearson SJ, Hussain SR. A review on the mechanisms of blood-flow restriction resistance training-induced muscle hypertrophy. Sports Med. 2015 Feb;45(2):187-200. doi: 10.1007/s40279-014-0264-9. — View Citation
Thijssen DH, Dawson EA, Tinken TM, Cable NT, Green DJ. Retrograde flow and shear rate acutely impair endothelial function in humans. Hypertension. 2009 Jun;53(6):986-92. doi: 10.1161/HYPERTENSIONAHA.109.131508. Epub 2009 Apr 20. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change from baseline vascular function at 2 weeks | Flow-mediated dilation evaluated by an ultrasound machine | Baseline measurement and measurement at 2 weeks | |
Primary | Change from baseline muscle strength at 2 weeks | Measured by a cable machine in the gym | Baseline measurement and measurement at 2 weeks | |
Primary | Change from baseline grip strength at 2 weeks | Measured by a hand dynamometer | Baseline measurement and measurement at 2 weeks | |
Secondary | Change from baseline body fat percentage at 2 weeks | Measured by a bioelectrical impedance analysis machine | Baseline measurement and measurement at 2 weeks | |
Secondary | Change from baseline fat mass at 2 weeks | Measured by a bioelectrical impedance analysis machine | Baseline measurement and measurement at 2 weeks | |
Secondary | Change from baseline lean body mass at 2 weeks | Measured by a bioelectrical impedance analysis machine | Baseline measurement and measurement at 2 weeks | |
Secondary | Blood flow responses to different types of cuff | Measured by an ultrasound machine | Baseline measurement | |
Secondary | Blood flow responses to different types of cuff | Measured by an ultrasound machine | At 2 weeks | |
Secondary | Change from baseline arterial stiffness at 2 weeks | Evaluated by the Omron VP-1000plus device (Non-invasive measurement) | Baseline measurement and measurement at 2 weeks | |
Secondary | Change from baseline blood lactate concentration | Measured by a lactometer | At 10 minutes before the training sessions (baseline measurement) and at 10 minutes after the training sessions | |
Secondary | Changes from baseline heart rate at the end of each exercise during all the training sessions | Measured by a heart rate monitor | At 10 minutes before the training sessions (baseline measurement), at 10 minutes, 20 minutes, and 30 minutes during the training sessions | |
Secondary | Change from baseline blood pressure at the end of each exercise during all the training sessions | Measured by an Omron digital blood pressure monitor | At 10 minutes before the training sessions (baseline measurement), at 10 minutes, 20 minutes, and 30 minutes during the training sessions | |
Secondary | Change of the perceived exertion | Borg rating of perceived exertion scale | At 10 minutes, 20 minutes, and 30 minutes during the training sessions |
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