Endothelial Function Clinical Trial
Official title:
Red Blood Cells as a Reflection of Endothelial Function in Old Age
NCT number | NCT02265003 |
Other study ID # | Anaemie |
Secondary ID | 14-016 |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | July 2012 |
Est. completion date | December 31, 2020 |
Verified date | February 2021 |
Source | Heinrich-Heine University, Duesseldorf |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The aim of this study is to find out, how far red blood cells reflect age-depended changes in endothelial function.
Status | Completed |
Enrollment | 140 |
Est. completion date | December 31, 2020 |
Est. primary completion date | December 31, 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Groups 1-3: Inclusion Criteria: - healthy subjects - informed consent Exclusion Criteria: - hypertension (blood pressure =140/90 mmHg), - hypercholesterolemia (LDL =250 mg/dl, HDL =45 mg/dl), - diabetes mellitus (fasting plasma glucose =128 mg/dl) - acute inflammation (CRP >0.5 mg/dl) - malignant diseases - heart failure (NYHA III-IV) - arrhythmia of high degree - acute or terminated kidney disease - cardiovascular diseases ( cardiac artery disease, peripheral vascular disease and cerebrovascular diseases) - anemia - pregnancy Group 4 : Inclusion Criteria: - angiographical signs of apparent atherosclerosis (cardiac artery disease or peripheral vascular disease or degenerative valvular heart disease) - informed consent Exclusion Criteria: - Hypertension (blood pressure =140/90 mmHg), - Hypercholesterolemia (LDL =250 mg/dl, HDL =45 mg/dl), - Diabetes mellitus (fasting plasma glucose =128 mg/dl) - acute inflammation (CRP >0.5 mg/dl) - malignant diseases - heart failure (NYHA III-IV) - arrhythmia of high degree - acute or terminated kidney disease - cardiovascular diseases ( cardiac artery disease, peripheral vascular disease and cerebrovascular diseases) - anemia - pregnancy |
Country | Name | City | State |
---|---|---|---|
Germany | University Hospital Duesseldorf | Duesseldorf |
Lead Sponsor | Collaborator |
---|---|
Heinrich-Heine University, Duesseldorf |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Determination of endothelial function | measured as flow-mediated vasodilation | baseline | |
Secondary | Determination of nitric oxide(NO)-pool in red blood cells and blood plasma | baseline | ||
Secondary | Determination of erythrocytes parameter | It will be determinated: oxidative status, signalling of nitric oxide, function, creation, amount and aging of red blood cells, cell-to-cell-interaction, microRNA and inflammation | baseline | |
Secondary | Cardiovascular Parameter | It will be determinated: hemodynamic, microcirculation and physicomechanic | baseline |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03301402 -
Air Purifier to Improve Endothelial Function and Carotid Intima Thickness
|
N/A | |
Recruiting |
NCT02500329 -
Effect of Gemigliptin or Acarbose on Endothelial Function in Type 2 DM Patients
|
Phase 4 | |
Completed |
NCT01947790 -
Pioglitazone Regress Left Ventricular Mass in Type 2 Diabetes With Ischeamia Heart Disease
|
Phase 4 | |
Completed |
NCT01028599 -
Effect of Physical Training on Oxygen Uptake and Endothelial Function in Heart Transplant Recipients
|
N/A | |
Completed |
NCT00575120 -
Endothelial Function Assessed With BOLD-MRI
|
N/A | |
Active, not recruiting |
NCT05451641 -
Blood Flow Restriction Resistance Training Intervention on Vascular Function
|
N/A | |
Completed |
NCT01713374 -
Physiological Assessment of the Endothelium - Circadian Rhythm and Role of the Sympathetic Nervous System
|
N/A | |
Completed |
NCT03651713 -
Hyperglycemia, Exercise, and Endothelial Function
|
N/A | |
Completed |
NCT00844714 -
Cardiovascular Risk Markers in Patients With Rheumatoid Arthritis: Effect of Rituximab Therapy
|
N/A | |
Completed |
NCT01256957 -
Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health
|
N/A | |
Completed |
NCT00967252 -
Impact of Chronic Statin Use During Surgery on Inflammation and Infection Rates
|
N/A | |
Completed |
NCT00845013 -
Epidemiology and Pathogenesis of HIV-Associated Pulmonary Hypertension
|
||
Completed |
NCT00728221 -
Evaluation and Standardization of Ginseng and it's Components for Blood Pressure Regulation
|
Phase 2 | |
Completed |
NCT00534651 -
Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease
|
Phase 4 | |
Recruiting |
NCT04689477 -
Non-invasive Characterization of Systemic Microvascular Reactivity by Near-infrared Diffuse Optical Spectroscopy in COVID-19 Patients
|
||
Completed |
NCT01610401 -
The Metformin-FMD Trial
|
Phase 4 | |
Completed |
NCT01829542 -
Dose-dependent Effects of Blueberry Polyphenols on Endothelial Function in Healthy Individuals
|
N/A | |
Terminated |
NCT00942643 -
Endothelial Damage and Atherosclerosis in Obstructive Sleep Apnea
|
N/A | |
Completed |
NCT05235958 -
VascuFit: Exercise and Vascular Aging
|
N/A | |
Not yet recruiting |
NCT06288828 -
The Efficacy of Aerobic Exercise Training on Autonomic Nervous System and Endothelial Function in Patients With Compensated Cirrhosis
|
N/A |