Endothelial Function Clinical Trial
The aim of this study is to evaluate the effect of the two different beta blockers
metoprolol and carvedilol on endothelial function in patients with either type two diabetes
or chronic heart failure.
Hypothesis: 1* Carvedilol compared to metoprolol has a favourable effect on endothelial
function.
2* Carvedilol compared to metoprolol has a favourable effect on insulin stimulated
endothelial function.
The study is conducted as an open parallel group study. Endothelial function and insulin
stimulated endothelial function was evaluated before and after a two months treatment period
with either of the two beta blockers.
Endothelial function is deteriorated in patients with type 2 diabetes and in patients with
chronic heart failure. Treatment with carvedilol improves survival in patients with chronic
heart failure compared to treatment with metoprolol. Carvedilol improves metabolic glucose
control in patients with diabetes compared to metoprolol.Carvedilol compared to metoprolol
also decreases the number of patients with new onset diabetes among patients with chronic
heart failure. The mechanism behind these findings has not been fully understood.
The purpose of this study is to investigate if carvedilol compared to metoprolol has a
favourable effect on endothelial function and insulin stimulated endothelial function, in
groups of patients with either diabetes or chronic heart failure.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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