Influence of Cardiorespiratory Fitness and Body Composition on Resting and Post-exercise Indices of Vascular Health in Young Adults

Endothelial Dysfunction Clinical Trial

Official title:

Influence of Cardiorespiratory Fitness and Body Composition on Resting and Post-exercise Indices of Vascular Health in Young Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06163456
• Other study ID #: 1810041426
• Status: Completed
• Phase: N/A
• Start date: December 2, 2019
• Est. completion date: November 29, 2023

Study information

• Verified date: November 2023
• Source: Towson University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This research is being done to determine whether acute exercise causes differences in numbers of novel blood factors associated with vascular health in college-aged adults across different physical activity habits. As only ~50% of cardiovascular (CV) events can be explained by traditional CV risk factors such as high blood pressure and high cholesterol, it is anticipated that this research will provide a more comprehensive look into novel risk factors that may better explain CV risk and that may be modifiable through regular physical activity.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 43
• Est. completion date: November 29, 2023
• Est. primary completion date: March 15, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 29 Years

Eligibility

Inclusion Criteria:

• 18-29 years of age; healthy male and female; Physically inactive, defined as participation in less than 20 min of continuous endurance exercise on fewer than 2 days/week; Recreationally active, defined as participation in 30 min/day of moderate-intensity cardiovascular activity on greater than 4 days/week; Highly active- defined as performing 30-60 min of moderate- to vigorous-intensity endurance exercise greater than 5 days/week.

Exclusion Criteria:

• currently pregnant, previously diagnosed coronary heart disease or congenital heart disease, serum total cholesterol >200 mg/dl, low-density lipoprotein cholesterol >130 mg/dl, high-density lipoprotein cholesterol < 35 mg/dl, fasting glucose >100 mg/dl, systolic blood pressure > 130 mmHg, diastolic blood pressure >90 mmHg, and BMI >30 kg/m2.

Related Conditions & MeSH terms

• Arterial Stiffness
• Endothelial Dysfunction

Intervention

Other:
• Acute submaximal exercise
30 min of treadmill running at 70% of the participants maximal oxygen consumption

Locations

Country	Name	City	State
United States	Towson University	Towson	Maryland

Sponsors (1)

Lead Sponsor	Collaborator
Towson University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	endothelial function	flow-mediated dilation	Baseline and 60 min post-exercise
Primary	arterial stiffness	augmentation index	Baseline and 60 min post-exercise