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NCT04962438 Clinical Trial

Effects of Anti-VEGF Targeted Drugs on Patients' Blood Pressure and Endothelial Function

Endothelial Dysfunction Clinical Trial

Official title:
Effects of Anti-VEGF Targeted Drugs on Patients' Blood Pressure and Endothelial Function

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04962438
Other study ID # Cardiac safety
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date July 5, 2019
Est. completion date December 30, 2021

Study information
Verified date June 2021
Source Peking University Third Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Explore the effects of anti-VEGF targeted drugs on blood pressure and endothelial function in cancer patients.

Description:

Thirty tumor patients with anti-VEGF drugs were selected. Demographic information and clinical information of all patients were collected before chemotherapy. Ambulatory blood pressure monitoring and endothelial function measurement (PWV, EndoPAT) were performed. Ambulatory blood pressure and PWV were reviewed at 2 weeks and 1 month. And EndoPAT, to evaluate the effects of anti-VEGF drugs on blood pressure and endothelial function in cancer patients.

Recruitment information / eligibility
Status Recruiting
Enrollment 30
Est. completion date December 30, 2021
Est. primary completion date December 1, 2021
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Tumor patients using anti-VEGF drugs Exclusion Criteria: - Hypertension, coronary heart disease, valvular heart disease, cardiomyopathy and other organic heart diseases, exclude liver and kidney failure, severe cerebrovascular disease, chronic obstructive pulmonary disease, rheumatic immune system disease

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Anti-VEGF
Anti-tumor drugs targeting the vascular endothelial growth factor (VEGF) signaling pathway

Locations
Country Name City State
China Peking University Third Hospital Peking Beijing

Sponsors (1)
Lead Sponsor Collaborator
Peking University Third Hospital

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Time ending 30 days after using the Anti-VEGF Targeted Drugs 1 month
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