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NCT04459182 Clinical Trial

Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome

Endothelial Dysfunction Clinical Trial

— EXODYS  

Official title:
Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome(OSA): EXODYS

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04459182
Other study ID # 2020-A01855-34
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 14, 2021
Est. completion date July 6, 2023

Study information
Verified date July 2023
Source University Hospital, Angers
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Evaluation of miRNA contained in exosomes in obese and OSA patients with endothelial dysfunction evaluated by digital plethysmography (ENDOPAT) compared to obese and OSA patients without endothelial dysfunction.

Description:

The aim of the study is to compare the content of exosomes between two goups of 20 patients, with and without endothelial dysfucntion. the endothelial function will be evaluated after polysomnography, on obese patients with OSA (AHI >15).

Recruitment information / eligibility
Status Completed
Enrollment 99
Est. completion date July 6, 2023
Est. primary completion date July 6, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - adult subject - Subject understands the study protocol and is willing and able to comply with study requirements and sign informed consent - Subject with OSA (defined by AHI >15/h) Exclusion Criteria: - cardiac or vascular desease

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• ENDOPAT
digital plethysmography

Locations
Country Name City State
France Frédéric GAGNADOUX Angers

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Angers

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary miRNA cointained in exosomes compare exosome content between obese-OSA patients with endothelial dysfunction and without immediately after the consultation
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