Endothelial Dysfunction Clinical Trial
Official title:
The Effect of an Acute Bout of Exercise on High-sugar Meal Induced Endothelial Dysfunction
The purpose of this study is to determine if postprandial (after a meal) endothelial (inner lining of blood vessels) dysfunction induced by a high sugar meal improves with a bout of exercise
Endothelial dysfunction is due to an imbalance between vasodilating and vasoconstricting
substances produced by the endothelium. An imbalance in these substances limits the ability
of the blood vessel to relax in response to a shear stress stimulus. Endothelial dysfunction
is a major risk factor for cardiovascular disease.
High-sugar intakes result in postprandial hyperglycemia and endothelial dysfunction. Exercise
may attenuate the endothelial dysfunction induced by a high-sugar meal. There are only two
studies that have examined the effect of exercise on endothelial dysfunction induced by
high-sugar intake. Both studies found that a bout of aerobic exercise attenuated the impaired
flow mediated dilation induced by high-sugar ingestion. Neither study measured important
markers of endothelial dysfunction such as blood nitric oxide, endothelin I, and angiotensin
II concentrations, however. In addition, whether the same results apply to older
post-menopausal women is unknown. Understanding how acute exercise affects meal-induced
endothelial dysfunction in older women is important given that age is related to endothelial
dysfunction and cardiovascular disease.
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