Endothelial Dysfunction Clinical Trial
Official title:
Effect of High Inspiratory Oxygen Fraction on Endothelial Function in Healthy Volunteers: a Randomized Controlled Cross-over Trial
The frequency of preoperative cardiac ischemia and the 30-days postoperative mortality is
much higher than previously assumed, with approximately 10 % of patients undergoing
non-cardiac surgery suffering from postoperative myocardial injury. A recent danish study
furthermore showed that patients treated with a high inspiratory oxygen fraction during
surgery had a higher 1 year mortality compared with patients treated with a low inspiratory
fraction. This was especially significant among patients undergoing cancer surgery. A
possible explanation, is that a high oxygen fraction results in oxidative stress and
endothelial dysfunction.
With this randomized cross-over study we wish to investigate the effect of a high
inspiratory oxygen fraction on the endothelial function among healthy male volunteers. The
primary outcome is the endothelial function assessed by the EndoPat system. Secondary
outcomes are changes in oxidative biomarkers. Heart rate variability (HRV) recordings will
serve as a measure for the effect of oxygen on the autonomic nervous system.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
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