Endothelial Dysfunction Clinical Trial
Official title:
Role of Acute and Chronic Hypoxemia for Vascular Function
Verified date | December 2014 |
Source | Heinrich-Heine University, Duesseldorf |
Contact | n/a |
Is FDA regulated | No |
Health authority | Germany: Ethics Commission |
Study type | Observational |
Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary
disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for
vascular function. For this purpose we measure capillary oxygen concentration and vascular.
Vascular function is assessed by flow-mediated dilation oft he brachial artery, forearm
blood flow and laser doppler perfusion imaging.
We hypothesize that hypoxemia leads to impaired vascular function.
Status | Completed |
Enrollment | 38 |
Est. completion date | September 2013 |
Est. primary completion date | September 2013 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 40 Years to 80 Years |
Eligibility |
Inclusion Criteria: - stable coronary artery disease - stable chronic obstructive pulmonary disease Exclusion Criteria: - acute myocardial infarction within 30 days - acute exacerbated COPD within 30 days - acute infections - severe acute or chronic renal failure - severe heart failure - atrial fibrillation - severe cardiac arrhythmia - hypotension - active malignant disease - active rheumatic disease - pulmonary hypertension with vasoactive therapy |
Observational Model: Case Control, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
Germany | Division of Cardiology, Pulmonary Disease and Vascular Medicine | Düsseldorf |
Lead Sponsor | Collaborator |
---|---|
Klinik für Kardiologie, Pneumologie und Angiologie |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Plasma nitrite concentration | Baseline | No | |
Primary | Flow-mediated dilation of the brachial artery | Baseline | No | |
Secondary | Forearm blood flow | Baseline | No | |
Secondary | Laser doppler perfusion | Baseline | No | |
Secondary | Intima-media thickness of the brachial artery | Baseline | No | |
Secondary | Fractional diameter change of the brachial artery | Baseline | No | |
Secondary | Endothelium-independent vasodilation of the brachial artery | Baseline | No |
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