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Effect of Proton Pump Inhibitors on Endothelial Function — PPI  

Endothelial Dysfunction Clinical Trial

Official title:
Do Proton Pump Inhibitors (PPIs) Increase Cardiovascular Risk? Effect of PPIs on Endothelial Function and ADMA.

Clinical Trial Summary

In this randomized controlled crossover study, the investigators propose to test the hypothesis that proton pump inhibitors (PPIs) increase plasma levels of asymmetric dimethylarginine (ADMA), which is a marker of endothelial dysfunction. The authors propose to evaluate ADMA concentrations and vascular function analysis in healthy volunteers and adults with a history of cardiovascular disease given PPI vs placebo for four weeks each.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02022280
Study type Interventional
Source Stanford University
Contact
Status Completed
Phase Phase 1
Start date March 2013
Completion date May 2014
View Details
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