The Cardiovascular Effects of Air Pollution: the Role of Nitric Oxide

Status Completed

Clinical Trial Summary

Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived particulate matter derived from traffic sources. Recently, it has been demonstrated that inhalation of diesel exhaust impairs vascular vasomotor tone and endogenous fibrinolysis. The mechanism underlying these detrimental vascular is unclear, but is thought to be via oxidative stress and altered bioavailability of endogenous nitric oxide. In these studies we plan to elucidate the role of endogenous nitric oxide (NO) in the adverse vascular responses observed following exposure to diesel exhaust.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Endothelial Dysfunction

Clinical Trial Details

NCT number	NCT00845767
Study type	Interventional
Source	University of Edinburgh
Contact
Status	Completed
Phase	N/A
Start date	April 2009
Completion date	July 2009

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02122198` - Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women	N/A
Completed	`NCT04156711` - Remote Ischemic Preconditioning in Patients Undergoing Acute Minor Abdominal Surgery	N/A
Recruiting	`NCT06133634` - Fisetin to Improve Vascular Function in Older Adults	Phase 1/Phase 2
Completed	`NCT05872139` - Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging	N/A
Recruiting	`NCT04558450` - Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN)	N/A
Terminated	`NCT03325933` - Resistance Training and Cardiometabolic Health	N/A
Not yet recruiting	`NCT05939934` - Impact of the Mandibular Advancement Device on Sleep Apnea During CPAP Withdrawal	N/A
Completed	`NCT02652975` - Anticancer Treatment of Breast Cancer Related to Cardiotoxicity and Dysfunctional Endothelium	N/A
Recruiting	`NCT02334839` - The Association Between Severity of Hypertensive Disorder During Pregnancy and Endothelial Dysfunction	N/A
Recruiting	`NCT02020044` - Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)	N/A
Completed	`NCT01775865` - Targeting Inflammation to Treat Cardiovascular Aging	Phase 2
Completed	`NCT01691404` - Study on the Effects of Epicatechin and Quercetin Supplementation on Vascular Function and Blood Pressure (FLAVO)	N/A
Terminated	`NCT01412216` - The Effects of Sedentarism on Vascular Function, Inflammation, and Insulin Resistance	Phase 2
Completed	`NCT01319344` - Effect of Eplerenone on Endothelial Function in Metabolic Syndrome	Phase 3
Completed	`NCT00848302` - Endothelial Function in Human Arteries	Early Phase 1
Completed	`NCT00987974` - Short Term Statin Treatment and Endothelial Dysfunction Due to Ischemia and Reperfusion Injury	Phase 4
Completed	`NCT00990730` - Atherosclerosis in Rheumatoid Arthritis	N/A
Completed	`NCT00532844` - A Phase 2, Pharmacokinetic (PK) Study of 6R-BH4 Alone or 6R-BH4 With Vitamin C in Subjects With Endothelial Dysfunction	Phase 2
Completed	`NCT00376246` - Effect of Ezetimibe on Flow-mediated Brachial Artery Reactivity in Healthy Subjects	Phase 4
Completed	`NCT00775099` - Combustion Derived Air Pollution and Vascular Function	N/A