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NCT00843271 Clinical Trial

Endothelial Dysfunction, Biomarkers, and Lung Function -Ancillary to MESA

Endothelial Dysfunction Clinical Trial

— MESA-LUNG  

Official title:
Endothelial Dysfunction, Biomarkers, and Lung Function (MESA LUNG)

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT00843271
Other study ID # AAAA7791
Secondary ID R01HL077612
Status Active, not recruiting
Phase N/A
First received February 12, 2009
Last updated January 12, 2012
Start date October 2004
Est. completion date November 2012

Study information
Verified date January 2012
Source Columbia University
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Observational

Clinical Trial Summary

The purpose of MESA-Lung is to assess the role of endothelial dysfunction and genetic susceptibility in subclinical COPD.

Description:

Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the United States, and morbidity and mortality from COPD continue to rise. Despite the magnitude of the problem, therapeutic options are limited - particularly in comparison to cardiovascular disease. Smoking cessation is essential to the treatment and prevention of COPD. However, although smoking is the principal cause of COPD, only a minority of smokers develops symptomatic COPD and many former smokers develop COPD years to decades after they have stopped smoking. The only other medical intervention proven to reduce mortality from COPD is supplemental oxygen therapy. There is therefore an urgent need for newer understandings of the pathophysiology of COPD that might lead to the development of better therapies for COPD.

MESA-Lung is ancillary of the ongoing Multi-Ethnic Study of Atherosclerosis (MESA). MESA-lung will utilize the various existing measures of endothelial function that have been already been collected in MESA (flow-mediated dilatation [FMD] and related biomarkers and gene polymorphisms) to test the hypotheses that the endothelial dysfunction occurs in the clinical COPD.

Other known NCT identifiers
  • NCT00094224

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 4359
Est. completion date November 2012
Est. primary completion date November 2012
Accepts healthy volunteers No
Gender Both
Age group 45 Years to 84 Years
Eligibility Inclusion Criteria:

- A random sample of MESA participants active at Exam 3 and/or 4.

Exclusion Criteria:

- MESA participants without MESA Exam 3 or 4 measurements.

- MESA participants without FMD measurements in Exam 1.

- MESA participants who have not consented to genetic testing.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (2)
Lead Sponsor Collaborator
Columbia University National Heart, Lung, and Blood Institute (NHLBI)

References & Publications (13)

Arehart E, Stitham J, Asselbergs FW, Douville K, MacKenzie T, Fetalvero KM, Gleim S, Kasza Z, Rao Y, Martel L, Segel S, Robb J, Kaplan A, Simons M, Powell RJ, Moore JH, Rimm EB, Martin KA, Hwa J. Acceleration of cardiovascular disease by a dysfunctional p — View Citation

Barr RG, Bourbeau J, Camargo CA, Ram FS. Tiotropium for stable chronic obstructive pulmonary disease: A meta-analysis. Thorax. 2006 Oct;61(10):854-62. Epub 2006 Jul 14. Review. Erratum in: Thorax. 2007 Feb;62(2):191. — View Citation

Barr RG, Mesia-Vela S, Austin JH, Basner RC, Keller BM, Reeves AP, Shimbo D, Stevenson L. Impaired flow-mediated dilation is associated with low pulmonary function and emphysema in ex-smokers: the Emphysema and Cancer Action Project (EMCAP) Study. Am J Re — View Citation

Barr RG, Stemple KJ, Mesia-Vela S, Basner RC, Derk SJ, Henneberger PK, Milton DK, Taveras B. Reproducibility and validity of a handheld spirometer. Respir Care. 2008 Apr;53(4):433-41. — View Citation

He K, Liu K, Daviglus ML, Mayer-Davis E, Jenny NS, Jiang R, Ouyang P, Steffen LM, Siscovick D, Wu C, Barr RG, Tsai M, Burke GL. Intakes of long-chain n-3 polyunsaturated fatty acids and fish in relation to measurements of subclinical atherosclerosis. Am J — View Citation

Jiang R, Burke GL, Enright PL, Newman AB, Margolis HG, Cushman M, Tracy RP, Wang Y, Kronmal RA, Barr RG. Inflammatory markers and longitudinal lung function decline in the elderly. Am J Epidemiol. 2008 Sep 15;168(6):602-10. doi: 10.1093/aje/kwn174. Epub 2 — View Citation

Jiang R, Camargo CA Jr, Varraso R, Paik DC, Willett WC, Barr RG. Consumption of cured meats and prospective risk of chronic obstructive pulmonary disease in women. Am J Clin Nutr. 2008 Apr;87(4):1002-8. — View Citation

Jiang R, Jacobs DR Jr, Mayer-Davis E, Szklo M, Herrington D, Jenny NS, Kronmal R, Barr RG. Nut and seed consumption and inflammatory markers in the multi-ethnic study of atherosclerosis. Am J Epidemiol. 2006 Feb 1;163(3):222-31. Epub 2005 Dec 15. — View Citation

Jiang R, Paik DC, Hankinson JL, Barr RG. Cured meat consumption, lung function, and chronic obstructive pulmonary disease among United States adults. Am J Respir Crit Care Med. 2007 Apr 15;175(8):798-804. Epub 2007 Jan 25. — View Citation

Jones DP, Camargo CA Jr, Speizer FE, Barr RG. Prospective study of short stature and newly diagnosed asthma in women. J Asthma. 2007 May;44(4):291-5. — View Citation

Lederer DJ, Benn EK, Barr RG, Wilt JS, Reilly G, Sonett JR, Arcasoy SM, Kawut SM. Racial differences in waiting list outcomes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008 Feb 15;177(4):450-4. Epub 2007 Nov 15. — View Citation

Mesia-Vela S, Yeh CC, Austin JH, Dounel M, Powell CA, Reeves A, Santella RM, Stevenson L, Yankelevitz D, Barr RG. Plasma carbonyls do not correlate with lung function or computed tomography measures of lung density in older smokers. Biomarkers. 2008 Jun;1 — View Citation

Varraso R, Fung TT, Barr RG, Hu FB, Willett W, Camargo CA Jr. Prospective study of dietary patterns and chronic obstructive pulmonary disease among US women. Am J Clin Nutr. 2007 Aug;86(2):488-95. — View Citation

* Note: There are 13 references in all — Click here to view all references

Outcome
Type Measure Description Time frame Safety issue
Primary Lung Function 2004-2011 No
Secondary Lung Density 2000-2011 No
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