Multimodal Imaging Based on Pathological & Genomic Characteristics

Status Recruiting

Clinical Trial Summary

Mitochondrial DNA mutations in normal gastric tissue, early gastric cancer and advanced gastric cancer were identified by single cell sequencing, and the origin of gastric stem cells was traced and new molecular markers were found. At the same time, organize industry-university-research-medical inspection joint research, aiming at the advanced layout of new structural and functional imaging technologies, combined with some new imaging technologies, such as holography, fluorescence, etc., to explore and develop a new composite endoscopic imaging technology that is advanced, original and suitable for China's national conditions, in order to develop a prototype of multimodal structural and functional imaging digestive endoscope without contrast agent.

Clinical Trial Description

In this study, on the basis of previous work, aiming at the visualization of key molecular functions of gastric cancer, a full-chain digestive endoscopic diagnosis system was constructed by using cross-scale medical imaging technology. Mitochondrial DNA mutations in normal gastric tissue, early gastric cancer and advanced gastric cancer were identified by single cell sequencing, and the origin of gastric stem cells was traced and new molecular markers were found. The tissue characteristics are analyzed by the full spectrum imaging device, and the location, distribution and aggregation of key molecules on the cell membrane are observed by the high resolution imaging device, so as to develop an imaging probe with high labeling efficiency and biosafety, and to explore its clinical application to realize the information fusion of structural and functional imaging in the evolution and diagnosis and treatment of gastrointestinal tumors. The structural heterogeneity and molecular heterogeneity of gastrointestinal tumors are clarified from the macro-micro levels, and the full-scale imaging system with the most comprehensive visualization and resolution ability is established from multi-information dimensions and multi-imaging scales. ;

Study Design

Related Conditions & MeSH terms

Endoscopy

Clinical Trial Details

NCT number	NCT05196243
Study type	Observational
Source	Affiliated Hospital to Academy of Military Medical Sciences
Contact	Yan Liu, MD
Phone	+8613911798288
Email	13911798288@163.com
Status	Recruiting
Phase
Start date	March 21, 2022
Completion date	July 1, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03298776` - I-Scan a Novel Endoscopic Tool for the Macroscopic Identification of Mucosal Lesions	N/A
Completed	`NCT02887378` - Protocol for Anatomopathologic Analysis of Biopsies Using Hot Clamps	N/A
Recruiting	`NCT01627171` - Colonoscopy Preparation Optimization for INpatients- COIN Study	Phase 4
Completed	`NCT02350933` - Endoscopic Evaluation of the Paediatric Airway After Prior Prolonged (>24 h) Tracheal Intubation	N/A
Completed	`NCT00671177` - Clinical Evaluation of Water Immersion Colonoscopy Insertion Technique	N/A
Completed	`NCT06033729` - Remifentanil Target Controlled Infusion Versus Standard of Care for Conscious Sedation During EBUS-TBNA	N/A
Withdrawn	`NCT04983498` - Enhanced Recovery Pathway for Endoscopy	Phase 4
Enrolling by invitation	`NCT04719117` - Retrograde Cholangiopancreatography AI Assisted System Validation on Effectiveness and Safety
Completed	`NCT03369197` - Nasal Continuous Positive Airway Pressure Versus Standard Care During Procedural Sedation for Gastrointestinal Endoscopy	N/A
Completed	`NCT04186390` - Learning Small Bowel Capsule Endoscopy
Completed	`NCT02714699` - Oral Hyoscine Butyl Bromide Versus Diclofenac Potassium Before Office Hysteroscopy	Phase 2/Phase 3
Completed	`NCT00614159` - Ketamine Compared to Propofol for Pediatric GI Endoscopy	N/A
Completed	`NCT04072328` - Propofol vs. Midazolam With Propofol for Sedative Endoscopy in Patients With Previous Paradoxical Reaction to Midazolam	Phase 2
Completed	`NCT04150237` - Using Simulation to Ensure Basic Competence in Gastroscopy
Completed	`NCT03287687` - Safety and Efficacy of CO2 for Endoscopy	Phase 4
Not yet recruiting	`NCT03351790` - Endoscopy Quality Study	N/A
Completed	`NCT04541667` - Is End Tidal CO2 Level Elevation During Upper Endoscopy With CO2 Gas Insufflation Physiologically Significant	N/A
Active, not recruiting	`NCT06168682` - Nasal CPAP - The Treatment IMpact on Oxygenation in High-risk Patients During Deep Sedation for Endoscopy	N/A
Recruiting	`NCT05479253` - AI-assisted Endoscopy Report System In Improving Reporting Quality	N/A
Recruiting	`NCT04903444` - Development and Validation of an Artificial Intelligence-based Biliary Stricture Navigation System in MRCP-based ERCP	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Multimodal Imaging Based on Pathological and Genomic Characteristics

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms