Effect of Anaesthesia on ER Stress in Cancer Patients

Endoplasmic Reticulum Stress Clinical Trial

Official title:

Evaluation the Effects of Anaesthetic Agents on Endoplasmic Reticulum Stress During Cancer Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03561831
• Other study ID #: KUH1160108
• Status: Completed
• Phase: N/A
• Start date: June 5, 2018
• Est. completion date: May 29, 2019

Study information

• Verified date: October 2021
• Source: Konkuk University Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Investigate the change in endoplasmic reticulum stress after cancer surgery according to different anaesthetics including propofol and sevoflurane.

Description:

We hypothesize propofol and sevoflurane based anesthesia would show different pattern of endoplasmic reticulum stress after cancer surgery in patients with cancer

Recruitment information / eligibility

• Status: Completed
• Enrollment: 53
• Est. completion date: May 29, 2019
• Est. primary completion date: May 29, 2019
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• patients with cancer

Exclusion Criteria:

• age under 19 years old

• allergy history to propofol or sevoflurane

• history of previous cancer

Related Conditions & MeSH terms

• Endoplasmic Reticulum Stress

Intervention

Drug:
• Propofol
propofol based anesthesia
• Sevoflurane
sevoflurane based anesthesia

Locations

Country	Name	City	State
Korea, Republic of	Konkuk University Medical Center	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Konkuk University Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in endoplasmic reticulum stress	Change in endoplasmic reticulum stress	baseline, postoperative 1 hours and 24 hours