Expression of Steroid Receptors in Endometrium

Endometrium Clinical Trial

Official title:

Expression of Steroid Receptors in Endometrium During the Early Follicular Phase in Stimulated Cycles

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00436462
• Other study ID #: UHR-4
• Status: Completed
• Phase: N/A
• First received: February 16, 2007
• Last updated: November 6, 2009
• Start date: December 2005
• Est. completion date: December 2007

Study information

• Verified date: November 2009
• Source: Aristotle University Of Thessaloniki
• Contact: n/a
• Is FDA regulated: No
• Health authority: Greece: Ministry of Health and Welfare
• Study type: Observational

Clinical Trial Summary

Expression of steroid receptors in endometrium during ovarian stimulation.

Description:

The purpose of this study is to examine in stimulated cycles a) whether there is a difference in expression of steroid receptors in stroma and glands of endometrium between different days during the follicular phase b)whether there are secretory changes detected by endometrium histology before ovulation c)whether there is an association between expression of steroid receptors in endometrium and exposure to oestradiol and progesterone during the follicular phase.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: December 2007
• Est. primary completion date: December 2007
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 20 Years to 39 Years

Eligibility

Inclusion Criteria:

• Treatment by IUI,

• BMI:18-29KGR/M2,

• No previous ovarian surgery,

• Normal hysterosalpingography,

• Estradiol < 80pg/ml and progesterone < 1.6ng/ml on day 2 of the cycle

Exclusion Criteria:

• Endometriosis,

• Severe male factor

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Endometrium

Locations

Country	Name	City	State
Greece	Unit of Human Reproduction, 1st Department of Obstetrics & Gynecology, AUTH, Papageorgiou Hospital	Thessaloniki

Sponsors (1)

Lead Sponsor	Collaborator
Aristotle University Of Thessaloniki

Country where clinical trial is conducted

Greece, 

References & Publications (2)

Kolibianakis E, Bourgain C, Albano C, Osmanagaoglu K, Smitz J, Van Steirteghem A, Devroey P. Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up. Fertil Steril. 2002 Nov;78(5):1025-9. — View Citation

Papanikolaou EG, Bourgain C, Kolibianakis E, Tournaye H, Devroey P. Steroid receptor expression in late follicular phase endometrium in GnRH antagonist IVF cycles is already altered, indicating initiation of early luteal phase transformation in the absence of secretory changes. Hum Reprod. 2005 Jun;20(6):1541-7. Epub 2005 Feb 10. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Steroid receptors expression in endometrium during early follicular phase		3 months	Yes
Secondary	In which day:day o+2, day 0+4 or day HCG		1 month	Yes