Endometritis Clinical Trial
Official title:
Efficacy and Side-Effects of Two Dosing Regimens of Doxycycline at Surgical Abortion: A Randomized Double-Blind Trial
This study is a randomized, double-blinded, controlled trial comparing two regimens of doxycycline for the prevention of infection after surgical abortion. One thousand women undergoing surgical abortion in the first trimester will be enrolled from the clinic at Tu Du Hospital, Ho Chi Minh City, Vietnam. The standard regimen has been 100 mg twice daily for 5 days after the abortion. Subjects will be randomized to the standard regimen or to take 200 mg doxycycline pre-operatively. Subjects found to have a positive Chlamydia EIA test will receive a 7-day course of doxycycline regardless of study group. Subjects will complete questionnaires of symptoms, including nausea and emesis in the recovery room after the procedure and at a single follow-up visit two weeks later. The primary outcome will be infection after abortion, defined below. Analyses will be performed including and excluding Chlamydia-positive subjects. Secondary outcomes will be the proportion with nausea, emesis, and other side-effects.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05049395 -
HFNO Reducing the Incidence of Hypoxia for Hysteroscopy Sedated With Propofol
|
N/A | |
Terminated |
NCT00386477 -
Vaginal Cleansing at Cesarean Delivery to Reduce Infection: A Randomized, Controlled Trial
|
N/A | |
Terminated |
NCT04163679 -
Vaginal Preparation and Azithromycin to Reduce Post Cesarean Infections
|
N/A | |
Recruiting |
NCT03960970 -
Two-drug Antibiotic Prophylaxis in Scheduled Cesarean Deliveries
|
Phase 2 | |
Completed |
NCT03459599 -
Antibiotic Prophylaxis in Ragged Placental Membranes
|
N/A | |
Completed |
NCT01762098 -
Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization
|
N/A | |
Withdrawn |
NCT01721616 -
Comparison Study of Cefazolin Versus Cefazolin Plus Azithromycin Prophylaxis in Post-Cesarean Endometritis
|
Phase 4 | |
Completed |
NCT01464840 -
The Pharmacokinetics of Azithromycin Prophylaxis for Cesarean Delivery
|
N/A | |
Completed |
NCT01235546 -
Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
|
N/A | |
Recruiting |
NCT04307069 -
Management of Prelabor Rupture of the Membranes at Term
|
N/A | |
Terminated |
NCT01587495 -
Pharmacokinetics and Safety of Ertapenem in the Postpartum Period
|
Phase 1 | |
Completed |
NCT03442218 -
Use of Antiseptic Solution for Vaginal Wash Before Cesarean Section
|
N/A | |
Not yet recruiting |
NCT01945450 -
Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial
|
N/A | |
Completed |
NCT00501033 -
A Prospective Comparative Study of Induction of Labor With a Cervical Ripening Double Balloon vs Foley Catheter
|
N/A | |
Completed |
NCT00500019 -
Uterine Flora During Elective and Urgent Cesarean Sections
|
N/A | |
Completed |
NCT00330278 -
Timing of Prophylactic Antibiotics for Cesarean Sections
|
N/A | |
Completed |
NCT00603603 -
Controlled Clinical Trial of Supplemental Oxygen for the Prevention of Post-Cesarean Infectious Morbidity
|
N/A | |
Completed |
NCT00858832 -
Reduction of Endometritis After Cesarean Section With the Routine Use of Methergine
|
N/A | |
Recruiting |
NCT04197167 -
Mid-Infrared Spectroscopy as a Real Time Diagnostic Tool for Chronic Endometritis
|
N/A | |
Completed |
NCT02402907 -
STRIPES Study: Study To Reduce Infection Post cEsarean Section
|
N/A |