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Comparing the Safety and Efficacy in the Use of Hormonal Therapy on Endometriosis Patients After Conservative Surgery — ENDOSafe  

Endometriosis Ovary Clinical Trial

Official title:
Comparing the Safety and Efficacy in the Use of Dienogest, Leuprolide Acetate, DMPA and Combined Oral Contraceptive Pills (Microgynon) on Endometriosis Patients After Conservative Surgery

Clinical Trial Summary

The goal of this clinical trial is to compare safety and efficacy in endometriosis patient after conservative surgery. The main question[s] it aims to answer are: 1. Health-related quality of life (HRQoL) 2. VAS score 3. Beta estradiol 4. TNF Alpha 5. Adnexal mass recurrence Participants will be randomized into 4 groups, each group will receive: 1. Leuprolide Acetate injection/month 2. Dienogest 2 mg/day 3. COC (mycrogynon)/day 4. DMPA injection 150mg/month Researcher will compare the efficacy and safety in the assigned group.

Clinical Trial Description

1. Beta estradiol level is measured in the serum, before and after treatment 2. TNF alpha is measured in the serum, before and after treatment 3. Evaluation of HRQoL using the Endometriosis Health Profile-30 (EHP-30) 4. VAS score will be recorded before and after treatment 5. Adnexal massa recurrence evaluation using USG ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06145438
Study type Interventional
Source Universitas Diponegoro
Contact Yuli Trisetiyono, SpOG (K)
Phone +6281229007845
Email razmaeda@gmail.com
Status Recruiting
Phase Phase 3
Start date September 4, 2023
Completion date April 4, 2024
View Details
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