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NCT04440397 Clinical Trial

Relationship Between Endoplasmic Reticulum Stress and Pain in Patients With Endometriosis

Endometriosis Clinical Trial

Official title:
Endoplasmic Reticulum Stress and Endometriosis Releated Pain

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04440397
Other study ID # xbpendo
Secondary ID
Status Completed
Phase
First received
Last updated
Start date March 17, 2020
Est. completion date August 4, 2020

Study information
Verified date August 2020
Source Kanuni Sultan Suleyman Training and Research Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The correlation between painful symptoms (dysmenorrhea, dysparonia, dysuria, chronic pelvic pain) symptoms and endoplasmic reticulum stress was investigated in 86 patients diagnosed with endometriosis. For this, xbp-1 (x box binding protein-1) level was measured in patients. XBP-1 is an endoplasmic reticulum stress indicator and is known to be involved in pain pathogenesis.

Description:

Women between the ages of 18-50 who were diagnosed with endometriosis by surgery and ultrasound, without known rheumatological or metabolic diseases were included in the study. Most of the patients are composed of newly diagnosed patients.

Recruitment information / eligibility
Status Completed
Enrollment 86
Est. completion date August 4, 2020
Est. primary completion date August 1, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 50 Years
Eligibility Inclusion Criteria:

- diagnosed endometriosis with ultrasound or surgery

- no metabolic diseases

- no rheumatological diseases

Exclusion Criteria:

- Immune modulator, hormonal, anti-inflammatory use history in the last 3 months

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• xbp-1 - endometriosis patients group
Patients diagnosed with endometriosis by surgery and ultrasound and whose xbp-1 level was examined

Locations
Country Name City State
Turkey Pinar Yalcin Bahat Istanbul I?stanbul

Sponsors (1)
Lead Sponsor Collaborator
Kanuni Sultan Suleyman Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary Evaluation of the correlations between the results of XBP-1 levels and the stages and pain symptoms of endometriosis. 5 months
Secondary serum XBP-1levels in patients wit endometriosis 5 months
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