Macrophage Migration Inhibitory Factor for Diagnosing Endometriosis and Its Severity

Endometriosis Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04091997
• Other study ID #: fayoum UH
• Status: Completed
• Start date: March 2016
• Est. completion date: September 2018

Study information

• Verified date: September 2019
• Source: Fayoum University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Endometriosis is a chronic disease affecting women of reproductive age. Macrophage migration inhibitory factor (MIF) is one of non-invasive blood biomarker that was detected in sera of endometriotic patients.The aim of this study was to evaluate the value of serum macrophage migration inhibitory factor in diagnosing endometriosis in women with infertility and chronic pelvic pain and correlate its level with the stage of the disease. Three hundred patient candidate for diagnostic laparoscopy were included in a case-control observational study

Description:

observational case-control study conducted in Fayoum University hospital from March 2016 till September 2018. Three hundred women candidate for diagnostic laparoscopy for either infertility or gynecologic chronic pelvic pain were included. The study group included patients with diagnostic criteria of endometriosis. The control group included other causes of infertility or pelvic pain.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 300
• Est. completion date: September 2018
• Est. primary completion date: September 2017
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 19 Years to 40 Years

Eligibility

Inclusion Criteria:

• postmenstrual women

• in childbearing period,

• presenting with either gynecologic chronic pelvic pain (CPP) or infertility

• indicated and fit for diagnostic laparoscopy.

• All women must have no hormonal treatment for the last 3 months and.

Exclusion Criteria:

• Women with bleeding tendency,

• suspicious of gynecologic malignancy or

• active infection

Related Conditions & MeSH terms

• Endometriosis

Intervention

Diagnostic Test:
• serum Eliza assay
laparoscopy and biopsy of lesions in endometriotic patients and seum ELIZA assay of microphage migration inhibitory factor

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Fayoum University Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	level of serum macrophage migration inhibitory factor and stage of the disease	serum MIF is a promising marker for noninvasive diagnosis of severity of endometriosis	one year