Endometriosis Clinical Trial
Official title:
Telomeres Evaluation in Endometriosis
The purpose of the study is to assess the telomere array of different endometriosis tissue
and endometrium from women with endometriosis compared to healthy women.
Our hypothesis is that telomere shortening and high telomerase activity will be found in
tissues from women with endometriosis.
The purpose of the study is to assess the telomere array of different endometriosis tissue
and endometrium from women with endometriosis compared to healthy women. Our hypothesis is
that telomere shortening and high telomerase activity will be found in tissues from women
with endometriosis, compared to women without endometriosis.
A prospective study that compares telomeres and telomerase levels in different lesions of
endometriosis and endometrial tissue of women with endometriosis and healthy women without
endometriosis. The study group will consist of women with suspected endometriosis facing
surgical treatment and the control group will consist of healthy women facing gynecologic
surgery for different indication.
We will sample endometrial tissue in both groups. In the study group we additionally will
sample endometriosis lesion.
The samples collected will test for histological diagnosis of endometriosis and verification
tests will be done to characterize the telomeres array and telomerase levels and other
characteristics for genomic instability such as spontaneous aneuploidy.
expect telomere shortening and high telomerase activity in endometrial tissue and in
endometriosis tissue sample, that won't characterize samples from women without
endometriosis.
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Observational Model: Case Control, Time Perspective: Prospective
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