Endometriosis Clinical Trial
Official title:
Genetic Polymorphisms of Mannan-binding Lectin (MBL) and Serum Levels of MBL in Patients With Endometriosis
The purpose of the study is to investigate the possible association between low levels of MBL and the development of endometriosis
Endometriosis is a chronic, inflammatory disease, affecting approximately 10% of the female
population. The pathogenesis of endometriosis is still unclear, but several studies have
indicated that the immune system is involved. It has been suggested that endometriosis
should be considered an autoimmune disease, considering the findings of elevated levels of
cytokines, decreased cell apoptosis, increased incidence of autoantibodies and a higher
frequency of other autoimmune diseases in endometriosis patients. MBL participates in the
innate immune defence by activating complement on the surfaces of microorganisms, but
several studies have suggested that MBL is also involved in autoimmune diseases. The
individual MBL level is highly variable due to a number of polymorphic sites in the
structural gene and in the promoter region, and approximately 12 % of the normal population
have very low serum MBL levels (<100 ng/ml).
The possible association between MBL and endometriosis has been investigated in two small
studies, in which no association was found. The aim of the present study is to investigate
the prevalence of individuals with low serum levels of MBL and with genotypes associated
with low MBL production in a larger group of endometriosis patients.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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