Endometriosis Clinical Trial
Long term treatment of progestin has been demonstrated to have an inhibitory effect on
endometrial angiogenesis and the proliferation of endometrial stromal cells. As a result,
progestin is now widely employed in the treatment of endometrial cancer, endometrial
hyperplasia, and dysfunction uterine bleeding. In the treatment of adenomyosis, however, the
beneficial effect of progestin was limited. It might imply that the behavior of endometrial
cells in women with adenomyosis is different from that in women without adenomyosis.
Our previous study revealed that the expression of killer inhibitory receptors (KIRs) on NK
cells was decreased in eutopic endometrium in women with adenomyosis. It may be a
compensatory effect in which the NK cytotoxicity is activated in order to wipe out the
abnormal endometrial cells that might go out of the eutopic site of endometrium. It implies
that the formation of adenomyosis might be due to “abnormal” endometrial tissues, but not
the aberrant local immunological dysfunction in myometrium. This finding is compatible with
previous reports in which eutopic endometrium obtained from women with endometriosis or
adenomyosis was found to behave differently from endometrium in unaffected women.
In this study, we try to collect endometrial tissues from women with and without
adenomyosis, and then purify the endometrial stromal cells from endometrium. The endometrial
stromal cells are cultured for 8 days with the supplement of medroxyprogesterone (MPA) or
danazol. Quantification of IL-6 and IL-8 mRNA in endometrial cells, and the concentrations
of IL-6 and IL-8 in cultured media will be done with real time RT-PCR and ELISA
respectively. The expression of different cytokines of endometrial cells in response to
progestin might be further elucidated after our experiment.
Status | Recruiting |
Enrollment | 45 |
Est. completion date | April 2005 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 35 Years to 50 Years |
Eligibility |
Inclusion Criteria: - women with adenomyosis - at early- to mid-secretory phases Exclusion Criteria: - postmenopausal - malignancy |
Observational Model: Defined Population, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
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