Endometrioma Clinical Trial
Official title:
Effect of Laparoscopic Ovarian Cystectomy of Endometrioma Versus Cyst Deroofing on Ovarian Reserve as Determined by Anti-mullerian Hormone and Antral Follicle Count: a Prospective Randomized Study.
The purpose of this study is to evaluate the impact of laparoscopic ovarian cystectomy versus laparoscopic cyst deroofing on ovarian reserve measured by serum levels of anti mullerian hormone and antral follicle count in patients with endometriomas.
One of the major concerns about excision of endometriomas is their negative effect on ovarian reserve because of follicle loss, removal of endometriomas has been associated with poorer performance in IVF procedures, and decreased ovarian volumes have also been reported after surgery.Ovarian reserve is defined as the functional potential of the ovary which reflects the number and quality of the follicles left in the ovary, and is well-correlated with the response to ovarian stimulation using exogenous gonadotrophin. Over the years, various tests and markers of ovarian reserve have been reported; the static tests include serum markers, such as basal FSH, inhibin-B and anti-Mullerian hormone (AMH), and ultrasonographic markers, such as ovarian volume and antral follicle count.This study will include 122 patients aged between 18 and 35 years who have been diagnosed with endometrioma (unilateral or bilateral) and they are candidates for laparoscopic surgery. They will be selected according to inclusion and exclusion criteria.they will be randomized into two study groups, one study group will undergo laparoscopic ovarian cystectomy, the other study group will undergo laparoscopic cyst deroofing.AMH,AFC and ovarian volume will be measured pre-operative and post-operative. ;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01268930 -
Comparison of Hemostatic Matrix and Bipolar Coagulation in Surgical Treatment of Endometriomas
|
N/A | |
| Completed |
NCT05323539 -
Comparison of Thyroid Volumes in Patients With and Without Endometrioma
|
N/A | |
| Recruiting |
NCT04178876 -
Comparison of Laparoscopic Endometrioma Stripping Versus Ethanol Sclerotherapy( CLESS)
|
N/A | |
| Recruiting |
NCT04151433 -
Conservative Endometrioma Surgery
|
N/A | |
| Completed |
NCT01942122 -
DLBS1442 for The Treatment of Pain in Patients Suspected Endometriosis
|
Phase 2/Phase 3 | |
| Withdrawn |
NCT00999479 -
Post Operative Continuous Active Combination Sex Steroids for the Prevention of Recurrent Endometrioma Formation
|
N/A | |
| Recruiting |
NCT03687398 -
Genomic Maps of Endometrial Tissues of Patients With Endometriosis and Healthy Controls
|
||
| Not yet recruiting |
NCT06377553 -
PET/MRI for Evaluation of Endometriosis
|
||
| Not yet recruiting |
NCT03788720 -
Suture of the Ovary After Enucleation of Ovarian Endometrioma
|
N/A | |
| Completed |
NCT01982526 -
Role of Anti Mullerian Hormone for Ovarian Reserve Determination of Preoperative and Postoperative Endometrioma Patients
|
||
| Recruiting |
NCT05962775 -
Ethanol Sclerotherapy Prior to ART
|
N/A | |
| Completed |
NCT03484546 -
Optimum Menstrual Cycle Time for Endometrioma Excision
|
||
| Recruiting |
NCT05637073 -
Effect of Management of the Endometrioma on Ovarian Reserve
|
||
| Completed |
NCT06219044 -
Evaluation of Ovarian Reserve and Recurrence Rate After DWLS Diode Laser OMA Vaporization
|
N/A | |
| Recruiting |
NCT03620838 -
Endometrioma Per se Versus Treatment Related Reduction in Ovarian Reserve (ERROR-2 Trial)
|
||
| Terminated |
NCT03571776 -
Anti-mullerian Hormone (AMH) After Treatment of Endometriomas With Alcohol Sclerotherapy Versus Surgery: Clinical Trial
|
N/A | |
| Enrolling by invitation |
NCT02472873 -
Efficacy of Aspiration and Sclerotherapy During Laparoscopy Using 95% Ethanol for the Treatment of Endometriomas
|
N/A | |
| Completed |
NCT04941833 -
Desogestrel for the Preoperative Treatment of Endometrioma Compared With Placebo
|
Phase 2/Phase 3 | |
| Completed |
NCT06274086 -
Two-session Catheter-directed Sclerotherapy Using Ethanol for Endometrioma
|
N/A | |
| Not yet recruiting |
NCT04452123 -
Endometrioma Treatment and Ovarian Function
|
N/A |