Treatment of Endometrial Hyperplasia With an Intrauterine Device (IUD)

Status Withdrawn

Clinical Trial Summary

The purpose of this research is to determine the effectiveness of the intrauterine device (IUD) called Mirena when compared to the Provera tablets used in treating this condition.

Clinical Trial Description

Endometrial hyperplasia without atypia is a condition usually caused by excessive stimulation of the uterine lining (endometrium) by estrogens, and may cause irregular bleeding as a presenting symptom, but rarely may progress to endometrial cancer, which makes treatment important. The only treatment approved so far is medroxyprogesterone acetate tablets (progesterone), also known as Provera. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00123175
Study type	Interventional
Source	Milton S. Hershey Medical Center
Contact
Status	Withdrawn
Phase	Phase 1/Phase 2
Start date	September 2009
Completion date	September 2011

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05378152` - Assessing the Benefit of Pipelle Biopsy in Patients With Postmenopausal Bleeding and an Atrophic-appearing Cavity	N/A
Completed	`NCT02100137` - Women With Asymptomatic Endometrial Hyperplasia	N/A
Completed	`NCT00242710` - Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations In Postmenopausal Women	Phase 3
Not yet recruiting	`NCT04191603` - TWO DİFFERENT ELECTROSURGERY DEVICES AS MONOPOLAR HOOC AND PLASMAKINETIC BIPOLAR SPATULA EFFECTIVENESS DURING COLPOTOMY	N/A
Completed	`NCT03032848` - Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients	Phase 4
Completed	`NCT00339651` - Preliminary Study of Endometrial Hyperplasia Groundwork for a Study to Define Precursors of Endometrial Cancer
Recruiting	`NCT01234818` - Management of Endometrial Hyperplasia With a LNG-IUS: Multicenter Study: KGOG2006	Phase 2
Recruiting	`NCT04362046` - Fertility Sparing Management of EndomeTrial Cancer and Hyperplasia	N/A
Active, not recruiting	`NCT05257057` - Frequency of Endometrial Cancer Precursors Associated With Lynch Syndrome
Completed	`NCT01499602` - Efficacy of LNG-IUS for Treatment of Non-atypical Endometrial Hyperplasia in Perimenopausal Women	N/A
Completed	`NCT00883662` - Mirena Observational Program	N/A
Completed	`NCT01074892` - A Study Comparing Mirena and Systemic Progestin for Endometrial Hyperplasia	Phase 4
Not yet recruiting	`NCT05903131` - A Behavioral Intervention to Promote Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia	Phase 2
Not yet recruiting	`NCT05829460` - Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia	Phase 2
Withdrawn	`NCT04897217` - Levonorgestrel-Releasing Intrauterine System (LNG-IUS) in the Management of Atypical Endometrial Hyperplasia	Phase 3
Recruiting	`NCT03176992` - Surgicel® & Endometrial Ablation in the Management of Perimenpausal Heavy Menstrual Bleeding	Phase 2
Not yet recruiting	`NCT00919919` - Efficacy and Tolerability Study of Progesterone Vaginal Tablets (Endometrin®) in Menopausal Women Treated by Estrogen	Phase 2
Recruiting	`NCT03207126` - Pilot Study: Can Ultrasound Guided Biopsy be Used as an Alternative to Hysteroscopy?	N/A
Recruiting	`NCT03207061` - Can 3D Ultrasound be Used as an Alternative to MRI to Assess Myometrial Invasion in Endometrial Cancer?	N/A
Completed	`NCT03207074` - Can the iKnife Distinguish Between Normal and Malignant Endometrial Tissue?	N/A