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Endometrial Diseases clinical trials

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NCT ID: NCT04184323 Withdrawn - Endometriosis Clinical Trials

SIRT-1 Antagonism for Endometrial Receptivity

SAFER
Start date: January 2022
Phase: Phase 2
Study type: Interventional

Progesterone resistance is mediated through epigenetic modification through SirT1 activation and is thought to contribute to infertility and progression of endometriosis. Endometriosis is a leading cause of unexplained IVF failure secondary to inflammatory changes that induce SirT1. The current study is designed to investigate a small molecule inhibitor of SirT1, in the clinical setting of In Vitro Fertilization and Embryo Transfer. The SAFER trial will compare EX-527 to placebo in a randomized, double-blind trial. Primary endpoints include Live Birth Rate (LBR) and secondary outcomes include pregnancy rate (PR), miscarriage rate (MR) and implantation failure rate.