| Eligibility |
Inclusion Criteria:
1. Age = 18 years.
2. Patients must have had measurable stage III,IVA or recurrent endometrial cancer,and
not suitable for curative radiotherapy or surgery.
3. All patients were required to have histologic confirmation of the original primary
tumor (submission of pathology report(s) is required). Patients with the following
histologic types were eligible: Endometrioid adenocarcinoma, serous adenocarcinoma,
mucinous adenocarcinoma, dedifferentiated/undifferentiated carcinoma, clear cell
adenocarcinoma, mixed epithelial carcinoma, carcinosarcoma, etc.
4. The subject has not received systematic chemotherapy in the advanced or recurrent
disease, but is allowed to receive neoadjuvant therapy, adjuvant therapy (including
chemotherapy, radiotherapy, or endocrine therapy) in the initial treatment stage, and
the last adjuvant chemotherapy is required to be completed at least 6 months before
enrollment. The final adjuvant radiotherapy, palliative radiotherapy (such as
radiotherapy for bone metastases), and endocrine therapy should be completed at least
3 weeks before enrollment. For palliative radiotherapy of central nervous system (CNS)
diseases, washout is allowed for one week.
5. Recurrent endometrial cancer or advanced endometrial cancer that are not suitable for
local treatment (including those with extensive abdominal and pelvic lesions, distant
metastases, and those who cannot tolerate radiotherapy or surgery, if it is estimated
that patients who may achieve surgery or radiotherapy after treatment are not suitable
for enrollment).
6. Prior antiangiogenic therapy is permitted.
7. Signed Informed Consent Form (ICF).
8. Provide tumor tissue samples fixed in formalin and embedded in paraffin for
pathological examination
9. In patients with measurable disease, lesions are defined and monitored by RECIST v1.1.
10. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
11. Has adequate organ function as defined by the following criteria:
1) Blood routine examination standards to meet: (no blood transfusion within 14 days):
- Hemoglobin of =90 g/L, white blood cell (WBC) =3×109/L, absolute neutrophil count
(ANC) =1.5×109/L, platelets =100 ×109/L 2) Biochemical examination should meet the
following criteria:
- Total bilirubin = 1.5 × upper limit of normal (ULN)
- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) = 2.5 × ULN (however,
patients with known liver metastasis who have AST or ALT level = 5 × ULN may be
enrolled)
- Serum creatinine = 1.5 × ULN 3) Urine protein =(++) , or 24-hour urine protein
quantification less than 1 g; 4) International standard ratio (INR) and activated
partial thromboplastin time =1.5 uln (unless anticoagulant therapy is used because of
disease) ; 12. Adverse events from any previous treatment, except for symptomatic
stable sensory neuropathy or alopecia = CTCAE Grade 2, have returned to = CTCAE grade
1 or baseline, except anemia; 13. Women of childbearing potential should have a
negative serum or urine pregnancy test prior to receiving the first dose of study
treatment; and should be willing to use one acceptable contraception (i.e., oral
contraceptives, condoms, intrauterine devices [IUDs]) throughout the period of taking
study treatment and for at least 3 months after the last dose of study drug(s).
14. Life expectancy exceeds 3 months.
Exclusion Criteria:
1. Other malignant tumors in the past (within 5 years) or at the same time, excluding
cured local tumors (such as basal cell skin cancer, squamous cell skin cancer,
superficial bladder cancer, cervical carcinoma in situ, breast carcinoma in situ,
etc.) and breast cancer and thyroid cancer that have no recurrence more than 3 years
after the completion of radical surgery.
2. Had received immunotherapy in the past, it includes immune checkpoint inhibitors (such
as anti-PD-1 antibody, anti-PD-L1 antibody, anti-CTLA-4 antibody, etc.) , immune
checkpoint agonists (such as ICOS, CD40, CD137, GITR, OX40 antibody, etc.) , immune
cell therapy, etc. Such subjects may be admitted with the consent of the sponsor.
3. Has an active autoimmune disease that has required systemic treatment in the past 2
years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive
drugs). Replacement therapy (e.g., thyroxine, insulin or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a
form of systemic treatment.
4. Previous history of immunodeficiency; HIV antibody positive; Current long-term use of
systemic corticosteroids or other immunosuppressants
5. Subjects who are known to have active pulmonary tuberculosis (TB) and are suspected to
have active TB need to undergo clinical examination to exclude them; Known active
syphilis infection.
6. Known history of allogeneic organ transplantation and allogeneic hematopoietic stem
cell transplantation.
7. Previous history of non-infectious pneumonia/interstitial lung disease requiring
systemic glucocorticoid treatment or current presence of non-infectious pneumonia.
8. Serious infections occur within 4 weeks before the first administration, including but
not limited to comorbidities, sepsis, or severe pneumonia that require
hospitalization; Active infections (excluding antiviral treatment for hepatitis B or
C) that have received systemic anti-infective treatment within two weeks prior to the
first administration.
9. Untreated subjects with active hepatitis B (HBSAg positive and HBV-DNA above 1000
copies/ml (200 IU/ml) or above the lower limit of detection, whichever is higher), for
subjects with Hepatitis B, anti-HBV therapy was required during study treatment;
subjects with active hepatitis C (HCV antibody positive and HCV-RNA levels above the
lower limit of detection) .
10. Those who had a major surgical procedure or major trauma within 30 days before the
first dose, or who had a major surgical plan within 30 days after the first dose (at
the investigator's discretion); Minor local procedures (excluding central venous
catheterization via peripheral venipuncture and implantable venous accessport) were
performed within 3 days before the first dose.
11. Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent
drainage procedures.
12. There are currently uncontrolled comorbidities, including but not limited to
symptomatic congestive heart failure (grade 2 and above according to the New York
Heart Association functional classification), unstable angina, acute myocardial
ischemia, poorly controlled arrhythmia, decompensated liver cirrhosis, nephrotic
syndrome, uncontrolled metabolic disorders, severe active peptic ulcer disease or
gastritis, Mental illness/social status that may limit subjects' compliance with
research requirements or affect their ability to provide written informed consent.
13. Previous history of myocarditis, cardiomyopathy, and malignant arrhythmia. Unstable
angina, myocardial infarction, congestive heart failure, or vascular disease requiring
hospitalization (such as aortic aneurysm at risk of rupture), or other cardiac
impairment (such as poorly controlled arrhythmias, myocardial ischemia) that may
affect study drug safety evaluation within 12 months prior to first administration of
study drug; A history of esophageal Gastric varices, severe ulcers, unhealed wounds,
gastrointestinal perforation, abdominal fistula, tumor-related gastrointestinal
obstruction, intra-abdominal abscess, or acute gastrointestinal bleeding in the 6
months before the first dose; Any arterial thromboembolic event, NCI CTCAE version 5.0
Grade 3 or higher, venous thromboembolism, transient cerebral ischemia,
cerebrovascular accident, Hypertensive crisis, or hypertensive encephalopathy,
occurred within 6 months before the first dose; Acute exacerbation of chronic
obstructive pulmonary disease within 1 month of first dose
14. A history of incurable abdominal fistula or gastrointestinal perforation; During the
screening period, imaging revealed obvious tumor invasion of the intestinal wall.
15. During screening, imaging or clinical findings of gastrointestinal obstruction,
including incomplete obstruction.
16. Previous history of severe bleeding or coagulation disorders; during screening,
imaging showed that the neoplasm surrounded major blood vessels or had obvious
necrosis and cavitation, and the investigators believed that participation in the
study might increase risk of bleeding.
17. Toxicities from previous antitumour therapy did not resolve, defined as toxicities
that did not return to grade 0 or 1 of NCI CTCAE version 5.0, or levels specified in
the inclusion/exclusion criteria; Except for alopecia and sequelae of neurotoxicity
related to previous platinum therapy. For subjects who experienced irreversible
toxicity and are expected to not worsen after the administration of the study drug
(such as hearing loss), as well as subjects who have long-term toxicity caused by
radiotherapy and cannot be restored according to the judgment of the researcher, if
the researcher evaluates that the subject may benefit from the study treatment, they
are allowed to be included in the study.
18. Has received a live virus vaccine within 30 days prior to first administration of
study drug or plan to be administered during the study period.
19. Known allergy to any component of any investigational drug, known history of severe
hypersensitivity to other monoclonal antibody.
20. Known history of mental illness, substance abuse, alcohol, or drug abuse.
21. Is pregnant, breastfeeding women.
22. Any prior or current disease, treatment, or laboratory test abnormality that may
confound the study endpoints, interfere with subjects' full participation in the
study, or may not be in their best interest to participate in this study.
23. Local or systemic diseases caused by non-malignant tumors, or diseases or symptoms
secondary to tumors, which can lead to higher medical risk and/or uncertainty in
survival evaluation, such as tumor like leukemia reactions (white blood cell count>20
× 109/L), symptoms of cachexia (known to have lost more than 10% of body weight in the
3 months before screening), etc.
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