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Effects of PARP Inhibitor on Tumor Microenvironment in High-risk Endometrial Cancer Patients

Endometrial Cancer Clinical Trial

Official title:
Effects of PARP Inhibitor on Tumor Microenvironment in High-risk Endometrial Cancer Patients

Clinical Trial Summary

This is a window study where treatment-naïve patients will receive olaparib before definitive treatment. The aim is to evaluate the DNA damage and inflammatory response after PARP inhibitor.

Clinical Trial Description

Patients with high-risk endometrial cancers are prone to develop recurrence. The response rate to conventional chemotherapy in persistent or recurrent endometrial cancer is poor. Recent research demonstrated that immune checkpoint with or without targeted therapy was an effective treatment option. However, the change of immune landscape in the blood and tumor after PARPi is not clear. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05320757
Study type Interventional
Source The University of Hong Kong
Contact Lesley Lau
Phone 852-22554265
Email lsk382@hku.hk
Status Recruiting
Phase Early Phase 1
Start date April 1, 2022
Completion date March 31, 2025
View Details
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