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Endometrial Cancer Patientes MMR Deficient Comparing Chimiotherapy vs Dostarlimab in First Line — DOMENICA  

Endometrial Cancer Clinical Trial

Official title:
Randomized Phase III Trial in MMR Deficient Endometrial Cancer Patients Comparing Chemotherapy Alone Versus Dostarlimab in First Line Advanced/Metastatic Setting

Clinical Trial Summary

Phase 3, randomized, multicentre study to evaluate the efficacy and safety of dostarlimab versus carboplatin-paclitaxel in patients with MMR deficient relapse or advanced endometrial cancer.

Clinical Trial Description

Phase III, randomized, open label, multi-centre study. Randomization on a 1:1 ratio, stratification performed according to: - Prior adjuvant chemotherapy (yes or no) - Prior pelvic radiotherapy (yes or no) - Disease status: newly diagnosed advanced / metastatic disease versus relapse ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05201547
Study type Interventional
Source ARCAGY/ GINECO GROUP
Contact Ophélie BACONNET
Phone 01 84 85 20 20
Email obaconnet@arcagy.org
Status Recruiting
Phase Phase 3
Start date April 15, 2022
Completion date October 2029
View Details
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