Endometrial Cancer Clinical Trial
Official title:
Phase II Trial of Mirvetuximab Soravtansine (IMGN853) and Bevacizumab in Patients With Endometrial Cancer
IMGN853 is designed to inhibit cell division and cell growth of folate receptor 1 (FRα)-expressing tumor cells. The purpose of this study is to test the safety of IMGN853 and bevacizumab and see what effects (good and bad) that this combination treatment has on subjects with recurrent endometrial cancer.
SCREENING: During the screening portion of the study, the subject will need to have tumor
tissue tested and other exams to determine if s/he may proceed to the treatment part of the
study. The subject's tumor tissue will be tested from either a previous or recent surgery or
biopsy to see if it contains the FRα protein. If the tumor is positive and the patient meets
all other eligibility, then the subject may proceed to treatment.
TREATMENT: Study drugs (IMGN853 and bevacizumab) will be given by vein (IV) once each cycle
on day 1 of 21 day cycle.
Regular cancer care exams, tests, and procedures will occur. Additionally, an eye doctor
visit with complete eye examination every other treatment cycle. Subjects will also
self-administer eye drops as prescribed by the eye doctor.
Study participation is up to three years.
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