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A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) — DUET-3  

Hepatocellular Carcinoma Clinical Trial

Official title:
A Phase 1 Multiple-Dose Study to Evaluate the Safety and Tolerability of XmAb®23104 in Subjects With Selected Advanced Solid Tumors

Clinical Trial Summary

This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD/RD and regimen of XmAb23104, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb23104 monotherapy and combination therapy with ipilimumab in subjects with selected advanced solid tumors.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Advanced Solid Tumors
  • Breast Carcinoma That is Estrogen Receptor, Progesterone Receptor, and Her2 Negative
  • Breast Neoplasms
  • Carcinoma
  • Carcinoma, Non-Small-Cell Lung
  • Cervical Carcinoma
  • Colorectal Carcinoma
  • Colorectal Neoplasms
  • Endometrial Carcinoma
  • Endometrial Neoplasms
  • Gastric or Gastroesophageal Junction Adenocarcinoma
  • Hepatocellular Carcinoma
  • Histiocytoma, Malignant Fibrous
  • Lung Neoplasms
  • Melanoma
  • Melanoma (Excluding Uveal Melanoma)
  • Nasopharyngeal Carcinoma
  • Non-small Cell Lung Carcinoma
  • Pancreatic Carcinoma
  • Pancreatic Neoplasms
  • Renal Cell Carcinoma
  • Sarcoma
  • Small Cell Lung Cancer
  • Small Cell Lung Carcinoma
  • Squamous Cell Carcinoma of Head and Neck
  • Squamous Cell Carcinoma of the Head and Neck
  • Undifferentiated Pleomorphic Sarcoma
  • Urothelial Carcinoma
Clinical Trial Details
NCT number NCT03752398
Study type Interventional
Source Xencor, Inc.
Contact
Status Active, not recruiting
Phase Phase 1
Start date May 1, 2019
Completion date September 2025
View Details
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