Endometrial Cancer Clinical Trial
Official title:
Minimally and Non-invasive Methods for Early Detection and Progression of Endometrial Cancer
Endometrial cancer (EC) is the most frequent gynecological malignancy but there is currently
lack of both non-invasive diagnostic tools and novel markers to stratify patients based on
their risk of future recurrence. Patient care could be improved by advances in these two
aspects.
In the present study, the investigators aim to identify diagnostic serum metabolite and
protein biomarker signatures for early detection of cancer in asymptomatic high-risk
population and prognostic biomarkers for selection of patients with poor prognosis.
Rationale: Endometrial cancer (EC) is the most frequent gynaecological malignancy in the
developed world. Optimal treatment of EC depends on early diagnostics and pre-operative
stratification to appropriately select the extent of surgery and to plan further therapeutic
approach. Currently, invasive endometrial histology is the gold standard for diagnosis, as
there are no valid non-invasive methods available, and patient stratification is based on
histopathology and surgical findings. There is a great need for efficient and reliable
screening test for asymptomatic women with high risk of EC including Lynch syndrome patients
and tamoxifen treated patients. In addition, a prognostic test is needed to stratify
pre-operatively EC patients with high risk of progression in need of radical surgery together
with adjuvant chemo/ratio therapy from EC patients with good prognosis. In this project the
investigators are addressing this lack of non-invasive diagnostic and prognostic biomarkers
of EC.
Objective: the investigators aim to identify diagnostic serum metabolite and protein
biomarker signatures for early detection of cancer in asymptomatic high-risk population and
(secondary objective) prognostic biomarkers for selection of patients with poor prognosis.
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