Endometrial Cancer Clinical Trial
Official title:
Phase II Trial of Aminopterin in Patients With Persistent or Recurrent Endometrial Carcinoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of aminopterin in treating patients who
have refractory or recurrent endometrial cancer.
OBJECTIVES: I. Estimate the antitumor activity of aminopterin in patients with persistent,
recurrent, or refractory endometrial carcinoma who have failed prior first line cytotoxic
chemotherapy. II. Determine the quantitative and qualitative toxic effects of aminopterin in
this patient population. III. Determine the overall patient survival and time to progression
of these patients. IV. Assess the pharmacokinetic profile of these patients.
OUTLINE: Patients receive oral aminopterin every 12 hours twice weekly. Treatment continues
for up to 15 months in the absence of disease progression or unacceptable toxicity. Patients
are followed every 3 months until death.
PROJECTED ACCRUAL: A total of 15-25 patients will be accrued for this study.
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