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Evaluation of The Effect of 980nm Diode Laser Intracanal Irradiation on Levels of Interleukin-8 Expression

Endodontically Treated Teeth Clinical Trial

Official title:
Evaluation of The Effect of 980nm Diode Laser Intracanal Irradiation on Levels of Interleukin-8 Expression in Lesions Refractory to Endodontic Treatment: A Randomized Control Trial

Clinical Trial Summary

This clinical trial will be conducted to evaluate the amount of Il-8 expression before and after the application of intracanal irradiation with diode laser 980 nm versus placebo in failed endodontic cases with periapical lesions.

Clinical Trial Description

- Thorough medical and dental history for the eligible patients - Thorough intraoral and extraoral diagnosis - Local anesthesia - Isolation and removal of any previous filling or restoration - Removal of old gutta percha and establish patency to the full working length. - 1st sample: will be collected using 3 sterile paper points - Chemo-mechanical preparation. - 2nd sample collection • Laser group: The canals will be irradiated with a high-power diode laser, with wavelength of 980 nm, maximum output of 3 watts and coupled with a fiber optic tip of 200 µm diameter. • Mock laser application (Placebo group): The fiberoptic tip will be inserted inside the root canal, mimicking the laser irradiation, but not activated. - 3rd sample collection - A piece of dry cotton will be placed in the access cavity, and then will be sealed with glass ionomer filling material - 2nd visit: 1 week later, 4th sample collection then Obturation - Number of visits & follow up period: Two visits ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05603988
Study type Interventional
Source Cairo University
Contact
Status Completed
Phase N/A
Start date April 14, 2021
Completion date April 27, 2022
View Details
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