Etco2 Levels on the End-tidal Concentration of Sevoflurane

End-tidal Carbon Dioxide Clinical Trial

Official title:

The Effect of Different Etco2 Levels on the End-tidal Concentration of Sevoflurane in Patients Undergoing Laparoscopic Cholecystectomy

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05778968
• Other study ID #: MAC of sevoflurane
• Status: Recruiting
• Phase: N/A
• Start date: February 1, 2023
• Est. completion date: August 2024

Study information

• Verified date: April 2024
• Source: Tanta University
• Contact: tarek A Mostafa, MD
• Phone: +20403288260
• Email: dr.tarek311[@]yahoo.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

he assessment of adequate levels of anaesthesia traditionally relies not only on a patient's movement but also on the hemodynamic response (or both) to a surgical stimulus

Description:

Currently a derivative of MAC namely, end tidal partial pressure (FET) displayed on the work station as concentration , maybe an alternative useful measure of the anaesthetic effect of an inhaled anaesthetic agent

. Many pharmacological factors have been associated with alterations in MAC and Mac derivatives such as nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics, and anesthetics.

However, few studies have focused on physiological factors, such as hypercarbia or hypocarbia. A correlation has been found between Paco2 and Etco2 in ventilated patients with healthy lungs. Some authors have suggested that Etco2 could be considered appropriate for estimating Paco2 even in critical patients. Knowledge of the effects of Paco2 on end tidal concentration of sevoflurane among patients undergoing laparoscopic cholecystectomy may help anaesthesiologists titrate sevoflurane carefully and precisely during different mechanical ventilation settings to avoid dose-dependent hypotension, impaired cardiac contractility, and hypothermia caused by excessive anaesthetic depth of sevoflurane.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 90
• Est. completion date: August 2024
• Est. primary completion date: June 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 30 Years to 65 Years

Eligibility

Inclusion Criteria:

• American Society of anaesthesiologist ASA physical status I, II

• admitted for laparoscopic cholecystectomy

Exclusion Criteria:

• Refusal of patients.

• Patients with renal or liver dysfunction.

• Patients with chronic pain other than cholelithiasis.

• Cardiac disorders as uncontrolled hypertension, arrhythmia, Ischaemic heart disease, valvular heart disease and pulmonary hypertension.

• Patient with haematological disorder as Sickle cell disease.

• Chest patient as asthma, COPD.

• Combined surgery .

• History of allergy to any of the study drugs.

• Patients with communication problems, cognitive dysfunction, or psychological disorders.

• Patients who received analgesics or sedatives 24 h before a scheduled surgery.

• Alcohol or drug abuse.

Related Conditions & MeSH terms

• End-tidal Carbon Dioxide

Intervention

Procedure:
• low etco2
Etco2 levels will be adjusted at levels ranging between 25 mm Hg and 30 mm Hg
• normal etco2
Etco2 levels will be adjusted at levels ranging between 31 mm Hg and 40 mm Hg
• high etco2
Etco2 levels will be adjusted at levels ranging between 41 mm Hg and 45 mm Hg

Locations

Country	Name	City	State
Egypt	tarek Abdelhay Mostafa	Tanta	El Gharbyia

Sponsors (1)

Lead Sponsor	Collaborator
Tanta University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	end tidal concentration of sevoflurane	end tidal concentration of sevoflurane is measured by multiple gas analyser during operation	Total time of operation