End-Stage Liver DIsease Clinical Trial
Official title:
Efficacy and Safety of Different Frequencies of Human Umbilical Cord-mesenchymal Stem Cells Through Peripheral Vein in Patients With End-stage Liver Disease
Stem cells are non-terminal cells that can self renew and replicate through symmetric or asymmetric division, with the potential to differentiate into different types of cells and tissues. Multiple studies have shown that mesenchymal stem cell has good safety and effectiveness in improving acute or chronic liver injury. Randomized controlled trials have confirmed the efficacy of single infusion of stem cells in treating ESLD. It seems that the multiple infusion is better than single infusion.
Ninety-two participants with end-stage liver disease admitted to the Department of Gastroenterology of the General Hospital of Northern Theater Command are expected to be enrolled over a period of 1 year. The participants will be randomly divided into single-infusion and double-infusion stem cell groups by peripheral vein. The investigators will observe alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, albumin, prothrombin time, international normalized ratio, model for end-stage liver disease score, and Child-Pugh score in patients at weeks 24 post-infusion. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Enrolling by invitation |
NCT05001009 -
Goals of Care Conversations Study
|
N/A | |
| Completed |
NCT01707810 -
Prospective Trial Comparing Conventional Versus Piggyback Method in Venous Drainage of the Transplanted Liver
|
N/A | |
| Terminated |
NCT00656266 -
Trial of Calcineurin Inhibitor-Sparing Immunosuppression Regimen in Pediatric Liver Transplantation
|
Phase 4 | |
| Completed |
NCT02166177 -
Safety and Efficacy Study of Regulatory T Cell Therapy in Liver Transplant Patients
|
Phase 1/Phase 2 | |
| Enrolling by invitation |
NCT02478151 -
Using Ex-vivo Normothermic Machine Perfusion With the Organox Metra™ Device to Store Human Livers for Transplantation
|
Phase 1 | |
| Completed |
NCT00913276 -
Conditioning With Volatile Anesthetics in Liver Transplantation
|
N/A | |
| Completed |
NCT04572373 -
Supplements SMOF in TPN for Liver Transplantation Recipients
|
||
| Not yet recruiting |
NCT05750329 -
Liver Transplantation With Two-stage Liver Resection in Unresectable Liver Cancer , Metastases or Emd-stage Liver Disease (LTLR-LC)
|
N/A |