End Stage Liver Disease Clinical Trial
Official title:
Pilot Study of the Liver Live Donor Champion Program
In this pilot study, investigators plan to enroll liver transplant candidates and a "Live Donor Champion" for an abridged two- or three-month program that provides education and advocacy training in order to expand access to live donor liver transplantation. Investigators have created two versions of the same program and based on feedback from participants and staff, investigators aim to analyze the efficacy of the Liver Liver Donor Champion program on this patient population.
In the United States, more than 13,000 patients are on the waiting list to receive a liver transplant. Although more than 6,000 liver transplants are performed every year, at least 1,700 patients die each year while on the waiting list. Livers are allocated to patients based on how sick the participants are, with sicker patients receiving priority. Living donation offers patients the option of transplant before patients get very sick, significantly decreasing the time patients wait for a liver. Livers from living donors are usually of excellent quality because donors are evaluated extensively and only allowed to donate if patients are in very good health. Living donation not only saves the life of the liver transplant candidate but also frees up a liver for a patient on the waiting list who does not have that option. A number of studies have attempted to understand barriers to finding a living donor. Multiple surveys have suggested that the educational needs are not met for both transplant candidates and potential donors. Furthermore, lack of knowledge and understanding of the consequences of donation may aggravate candidate fear of donor risks, contributing to candidate reluctance in allowing friends or family to donate. Finally, having an inadequate communication skill set in how to ask someone to donate is one of the most prevalent barriers reported by transplant candidates. A "Live Donor Champion" (LDC) is a friend, family member, or community member who serves as an advocate for the candidate in participants' pursuit of living donation. Investigators' center has previously developed a six-month program that provides education and advocacy training to kidney transplant candidates and participants' LDCs; however, no program currently exists for liver transplant candidates. The instrumental support provided by the LDC from investigators' kidney program bridges a critical link between education and action. In pilot studies, candidates with an LDC were more likely to undergo live donor kidney transplantation than matched controls. In this pilot study, investigators plan to enroll liver transplant candidates and participants' LDCs for an abridged two- or three-month program that provides education and advocacy training in order to expand access to live donor liver transplantation. Investigators have created two versions of the same program and based on feedback from participants and staff, investigators aim to analyze the efficacy of the Liver Liver Donor Champion program on this patient population. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03557086 -
A Randomized Controlled Trial of an Advanced Care Planning Video Decision Support Tool for Patients With End-Stage Liver Disease
|
N/A | |
Completed |
NCT04604860 -
Use of EL-FIT App to Promote Physical Activity
|
N/A | |
Completed |
NCT01933789 -
Improving Communication About Serious Illness
|
N/A | |
Recruiting |
NCT01724697 -
Safety and Efficacy of Human Bone Marrow Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
Recruiting |
NCT01728688 -
Safety and Efficacy of Human Autologous Peripheral Blood Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
Recruiting |
NCT01728727 -
Safety and Efficacy of Human Umbilical Cord Derived Mesenchymal Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT01412593 -
Intra-hepatic Artery Bone Marrow Derived Stem Cells Infusion for the Treatment of Advanced Liver Cirrhosis
|
Phase 1/Phase 2 | |
Completed |
NCT00374582 -
End Stage Liver Disease and Body Composition Assessment: Utilizing Bioelectric Impedance Analysis (BIA)
|
N/A | |
Completed |
NCT00249652 -
Transplant and Addiction Project (TAP) - 1
|
Phase 1/Phase 2 | |
Recruiting |
NCT05998330 -
LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease
|
N/A | |
Completed |
NCT04546048 -
The Early Strength Training Program in Post-transplant Liver Cases
|
N/A | |
Recruiting |
NCT04037995 -
Real World Study of End-stage Liver Disease in China
|
||
Recruiting |
NCT03870568 -
Functional Assessment in Liver Transplantation
|
||
Recruiting |
NCT03633812 -
Effect of Preoperative Beta Blocker Use Postoperative Renal Function in the Patients Undergoing Liver Transplantation
|
||
Active, not recruiting |
NCT02889094 -
French HIV-HBV Cohort
|
||
Completed |
NCT02444273 -
The Feasibility of a Prehabilitation Program in the Liver Transplant Population at Barnes-Jewish Hospital
|
N/A | |
Recruiting |
NCT01711073 -
Mobilization of Stem Cells With G-CSF and Mozobil in Patients With End Stage Liver Disease
|
Phase 1 | |
Not yet recruiting |
NCT06069050 -
SALT in Adolescents With End-stage Liver Disease
|
N/A | |
Recruiting |
NCT03228290 -
Functional Assessment in Liver Transplantation
|
||
Recruiting |
NCT04107883 -
Effect of Transfusion of Plasma on Endothelial During Liver Transplantation
|
N/A |