End Stage Liver Disease Clinical Trial
Official title:
Functional Assessment in Liver Transplant Candidates (FrAILT) Study
This will be a prospective cohort study of patients with liver disease. Subjects will undergo geriatric assessments of frailty, functional status, and disability using functional status measures at baseline and at every clinic visit in the pre-transplant setting. Subjects will also answer questions regarding quality of life, personality, and/or cognitive function. Subjects will again undergo assessments at every clinic visit through 12 months after transplant. Then, they will be followed annually.
Patients will be asked to perform the following study procedures: 1. Assessment of cognitive function, quality of life, and/or personality using cognitive tests and questionnaires. 2. Measures of frailty and disability selected to capture the multi-dimensional aspects of frailty including functional status and physiologic reserve: Fried Frailty Score: weakness (test of grip strength), exhaustion (patient interview), slowness (gait speed), low activity (patient interview) Short Physical Performance Battery: repeated chair stands, balance testing with feet together, 13-foot walk 3. Laboratory tests will all be obtained from the medical record: creatinine, total bilirubin, INR, sodium, albumin. All of these tests are necessary for listing for liver transplantation. 4. Blood draw, urine and stool samples will be collected for a sub-group of 1000 patients. 5. Adipose, muscle, liver tissue, and blood will be collected during the liver transplant surgery for a sub-group of 1000 patients. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03557086 -
A Randomized Controlled Trial of an Advanced Care Planning Video Decision Support Tool for Patients With End-Stage Liver Disease
|
N/A | |
| Completed |
NCT04604860 -
Use of EL-FIT App to Promote Physical Activity
|
N/A | |
| Completed |
NCT01933789 -
Improving Communication About Serious Illness
|
N/A | |
| Recruiting |
NCT01728688 -
Safety and Efficacy of Human Autologous Peripheral Blood Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Recruiting |
NCT01724697 -
Safety and Efficacy of Human Bone Marrow Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Recruiting |
NCT01728727 -
Safety and Efficacy of Human Umbilical Cord Derived Mesenchymal Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT01412593 -
Intra-hepatic Artery Bone Marrow Derived Stem Cells Infusion for the Treatment of Advanced Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Completed |
NCT00374582 -
End Stage Liver Disease and Body Composition Assessment: Utilizing Bioelectric Impedance Analysis (BIA)
|
N/A | |
| Completed |
NCT00249652 -
Transplant and Addiction Project (TAP) - 1
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05998330 -
LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease
|
N/A | |
| Completed |
NCT04546048 -
The Early Strength Training Program in Post-transplant Liver Cases
|
N/A | |
| Active, not recruiting |
NCT03580629 -
Pilot Study of the Liver Live Donor Champion Program
|
N/A | |
| Recruiting |
NCT04037995 -
Real World Study of End-stage Liver Disease in China
|
||
| Recruiting |
NCT03870568 -
Functional Assessment in Liver Transplantation
|
||
| Recruiting |
NCT03633812 -
Effect of Preoperative Beta Blocker Use Postoperative Renal Function in the Patients Undergoing Liver Transplantation
|
||
| Active, not recruiting |
NCT02889094 -
French HIV-HBV Cohort
|
||
| Completed |
NCT02444273 -
The Feasibility of a Prehabilitation Program in the Liver Transplant Population at Barnes-Jewish Hospital
|
N/A | |
| Recruiting |
NCT01711073 -
Mobilization of Stem Cells With G-CSF and Mozobil in Patients With End Stage Liver Disease
|
Phase 1 | |
| Not yet recruiting |
NCT06069050 -
SALT in Adolescents With End-stage Liver Disease
|
N/A | |
| Recruiting |
NCT04107883 -
Effect of Transfusion of Plasma on Endothelial During Liver Transplantation
|
N/A |