Clinical Trials Logo
  1. Home
  2. End Stage Liver Disease
  3. NCT03109236

Autologous Endothelial Progenitor Cell Therapy for Reversal of Liver Cirrhosis

End Stage Liver Disease Clinical Trial

Official title:
Autologous Endothelial Progenitor Cell Therapy for Reversal of Liver Cirrhosis

Clinical Trial Summary

This proposal translates a hypothesis driven basic research into clinical setting to determine the potential of using autologous CD133+ cells to reverse fibrosis and improve clinical outcome for patients with end stage cirrhosis. This has significant impact on the management of cirrhosis.

Clinical Trial Description

This is a 2 arm randomised study patients with decompensated liver cirrhosis involving minimum of 23 and maximum of 33 patients in each arm. The investigators propose that transplantation of mobilized autologous CD133+ cells harvested from the bone marrow directly into the liver has the ability to replace and regenerate the damaged sinusoidal endothelium as well as normalize macrophage and Natural Killer (NK) cell function. The niche provided by the refenestrated endothelium can polarize the macrophage to antifibrotic phenotype as well as directly inactivate the activated myofibroblast, resulting in reversal of liver fibrosis and improvement in liver function. Transplantation of cells will be via intraportal route delivered by percutaneous cannulation of the portal vein system. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03109236
Study type Interventional
Source National University Hospital, Singapore
Contact Nur Halisah
Phone 66015193
Email mdcnhj@nus.edu.sg
Status Recruiting
Phase Phase 3
Start date August 24, 2017
Completion date December 31, 2023
View Details
See also
  Status Clinical Trial Phase
Completed NCT03557086 - A Randomized Controlled Trial of an Advanced Care Planning Video Decision Support Tool for Patients With End-Stage Liver Disease N/A
Completed NCT04604860 - Use of EL-FIT App to Promote Physical Activity N/A
Completed NCT01933789 - Improving Communication About Serious Illness N/A
Recruiting NCT01724697 - Safety and Efficacy of Human Bone Marrow Stem Cells for Treatment of HBV-related Liver Cirrhosis Phase 1/Phase 2
Recruiting NCT01728727 - Safety and Efficacy of Human Umbilical Cord Derived Mesenchymal Stem Cells for Treatment of HBV-related Liver Cirrhosis Phase 1/Phase 2
Recruiting NCT01728688 - Safety and Efficacy of Human Autologous Peripheral Blood Stem Cells for Treatment of HBV-related Liver Cirrhosis Phase 1/Phase 2
Not yet recruiting NCT01412593 - Intra-hepatic Artery Bone Marrow Derived Stem Cells Infusion for the Treatment of Advanced Liver Cirrhosis Phase 1/Phase 2
Completed NCT00374582 - End Stage Liver Disease and Body Composition Assessment: Utilizing Bioelectric Impedance Analysis (BIA) N/A
Completed NCT00249652 - Transplant and Addiction Project (TAP) - 1 Phase 1/Phase 2
Recruiting NCT05998330 - LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease N/A
Completed NCT04546048 - The Early Strength Training Program in Post-transplant Liver Cases N/A
Active, not recruiting NCT03580629 - Pilot Study of the Liver Live Donor Champion Program N/A
Recruiting NCT04037995 - Real World Study of End-stage Liver Disease in China
Recruiting NCT03870568 - Functional Assessment in Liver Transplantation
Recruiting NCT03633812 - Effect of Preoperative Beta Blocker Use Postoperative Renal Function in the Patients Undergoing Liver Transplantation
Active, not recruiting NCT02889094 - French HIV-HBV Cohort
Completed NCT02444273 - The Feasibility of a Prehabilitation Program in the Liver Transplant Population at Barnes-Jewish Hospital N/A
Recruiting NCT01711073 - Mobilization of Stem Cells With G-CSF and Mozobil in Patients With End Stage Liver Disease Phase 1
Not yet recruiting NCT06069050 - SALT in Adolescents With End-stage Liver Disease N/A
Recruiting NCT03228290 - Functional Assessment in Liver Transplantation