End Stage Liver Disease Clinical Trial
Liver disease is a common medical problem in Saudi Arabia. Early studies indicated that
around 10% of the Saudi population is either infected with hepatitis B or C. An estimated
12% of chronic HCV and HBV patients undergoing liver biopsy from Saudi centers have
cirrhosis. Of these 3-5% would decompensate yearly thereby requiring liver transplantation.
Based on the most recent national census figures, and a 1-2% prevalence rate of HBV and HCV
nationwide, an estimated 1,000 patients would require liver transplantation on a yearly
basis for decompensated cirrhosis.
Liver transplantation is the only available life saving treatment for patients with end
stage liver disease. Unfortunately less than 100 liver transplantations are performed in
Saudi Arabia in three centers. Around 100 other patients travel abroad for transplantation
annually while all other patients progressively deteriorate and eventually die from the
complications of decompensated liver cirrhosis.
In addition, even in patients who are listed for liver transplantation, often patients are
too sick to wait on the transplant list that often takes more than a year and the on-list
mortality is high. A procedure or an intervention that may help to stabilize liver function
in order to help patients survive on the transplant list while awaiting liver
transplantation would be of immense benefit. Examples of such interventions are already
approved and used in some centers like the MARS system.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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